(Q34097455)

31 July 2017

title

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors (English)

1 reference

31 July 2017

0 references

Paul G Wyatt

8

0 references

Ian H. Gilbert

object named as

Ian H Gilbert

9

0 references

Alan Fairlamb

object named as

Alan H Fairlamb

7

0 references

Daniel Spinks

1

object named as

Daniel Spinks

1 reference

31 July 2017

5

Julie A Frearson

1 reference

31 July 2017

Leah S Torrie

2

1 reference

31 July 2017

Stephen Thompson

3

1 reference

31 July 2017

Justin R Harrison

4

1 reference

31 July 2017

Kevin D Read

6

1 reference

31 July 2017

publication date

8 December 2011

1 reference

31 July 2017

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31 July 2017

volume

7

1 reference

31 July 2017

issue

1

1 reference

31 July 2017

page(s)

95-106

1 reference

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Target assessment for antiparasitic drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Comparative genomics of trypanosomatid parasitic protozoa

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Validation of Trypanosoma brucei trypanothione synthetase as drug target

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Ligand efficiency: a useful metric for lead selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Biosynthesis of trypanothione in Trypanosoma brucei brucei.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

The Parasite-Specific Trypanothione Metabolism of Trypanosoma and Leishmania

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Metabolism and functions of trypanothione in the Kinetoplastida

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320663

Kinetoplastids: related protozoan pathogens, different diseases

28 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Chemotherapy of human African trypanosomiasis: current and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Thiol-based redox metabolism of protozoan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Properties of trypanothione synthetase from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100420

Novel poly(ADP-ribose) polymerase-1 inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22162199

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CMDC.201100420

1 reference

release_lyrkj2m4ozatdnoiccmctnh32y

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lyrkj2m4ozatdnoiccmctnh32y

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3320663

1 reference

31 July 2017

1 reference