(Q34100506)

31 July 2017

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title

WASP: a key immunological multitasker (English)

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31 July 2017

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Siobhan O Burns

2

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Adrian Thrasher

object named as

Adrian J Thrasher

series ordinal

1

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publication date

1 March 2010

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Nature Reviews Immunology

31 July 2017

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31 July 2017

10

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31 July 2017

3

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31 July 2017

182-192

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The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

31 July 2017

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The WASP and WAVE family proteins

31 March 2020

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Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

31 March 2020

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

31 March 2020

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

31 March 2020

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Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization

31 March 2020

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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

31 March 2020

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The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement.

31 March 2020

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A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization

31 March 2020

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Human subtelomeric WASH genes encode a new subclass of the WASP family

31 March 2020

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WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport

31 March 2020

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A multiinstitutional survey of the Wiskott-Aldrich syndrome.

31 March 2020

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Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients

31 March 2020

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Clinical course of patients with WASP gene mutations

31 March 2020

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Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

31 March 2020

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Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia

31 March 2020

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A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene.

31 March 2020

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

31 March 2020

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Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

31 March 2020

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Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2.

31 March 2020

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Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation

31 March 2020

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A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

31 March 2020

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Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

31 March 2020

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A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells

31 March 2020

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Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex

31 March 2020

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Hierarchical regulation of WASP/WAVE proteins

31 March 2020

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Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

31 March 2020

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Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.

31 March 2020

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Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages

31 March 2020

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The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.

31 March 2020

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Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid

31 March 2020

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Phosphorylation of WASp is a key regulator of activity and stability in vivo

31 March 2020

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Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.

31 March 2020

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Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP

31 March 2020

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WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells

31 March 2020

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Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages

31 March 2020

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WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).

31 March 2020

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WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

31 March 2020

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Structure of the N-WASP EVH1 Domain-WIP Complex

31 March 2020

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Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP

31 March 2020

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Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation

31 March 2020

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Analysis of conformational changes in WASP using a split YFP

31 March 2020

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WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype

31 March 2020

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Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype

31 March 2020

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WIP: a multifunctional protein involved in actin cytoskeleton regulation.

31 March 2020

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WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation

31 March 2020

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A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

31 March 2020

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Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

31 March 2020

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Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

31 March 2020

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Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis

31 March 2020

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Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

31 March 2020

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WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function

31 March 2020

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Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome

31 March 2020

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Revertant somatic mosaicism in the Wiskott-Aldrich syndrome

31 March 2020

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Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome

31 March 2020

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Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.

31 March 2020

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Wiskott-Aldrich syndrome in a female

31 March 2020

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Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings

31 March 2020

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Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

31 March 2020

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Early deficit of lymphocytes in Wiskott-Aldrich syndrome: possible role of WASP in human lymphocyte maturation.

31 March 2020

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Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome

31 March 2020

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WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.

31 March 2020

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Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology.

31 March 2020

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The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse

31 March 2020

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Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.

31 March 2020

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Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production

31 March 2020

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Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

31 March 2020

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Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.

31 March 2020

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Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function

31 March 2020

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Combined immunodeficiency associated with DOCK8 mutations

31 March 2020

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Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

31 March 2020

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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

31 March 2020

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Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response

31 March 2020

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Innate-like recognition of microbes by invariant natural killer T cells

31 March 2020

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The contrasting roles of NKT cells in tumor immunity

31 March 2020

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Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells

31 March 2020

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The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.

31 March 2020

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Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells

31 March 2020

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Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages

31 March 2020

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Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation

31 March 2020

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Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

31 March 2020

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Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome

31 March 2020

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Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein

31 March 2020

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Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells

31 March 2020

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Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells

31 March 2020

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The mechanical integrin cycle.

31 March 2020

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Maturation of DC is associated with changes in motile characteristics and adherence

31 March 2020

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Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils

31 March 2020

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Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

31 March 2020

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Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect

31 March 2020

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NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.

31 March 2020

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The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells

31 March 2020

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Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

31 March 2020

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WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells

31 March 2020

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Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome

31 March 2020

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Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation

31 March 2020

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Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption

31 March 2020

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Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation

31 March 2020

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12 December 2020

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

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12 December 2020

Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome

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12 December 2020

Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome

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12 December 2020

Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine

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12 December 2020

Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation.

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12 December 2020

Identifiers

DOI

10.1038/NRI2724

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31 July 2017

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PubMed ID

20182458