(Q34107259)

English

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Alzheimer's disease

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5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Bin Liang

1

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Europe PubMed Central

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6 February 2020

Bao-Yu Duan

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Xiu-Ping Zhou

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Jia-Xin Gong

4

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6 February 2020

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1 July 2010

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6 February 2020

Journal of Biological Chemistry

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6 February 2020

285

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6 February 2020

36

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6 February 2020

27737-27744

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Europe PubMed Central

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6 February 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2934641/fullTextXML

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Calpain-mediated N-cadherin proteolytic processing in brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Morris water maze: procedures for assessing spatial and related forms of learning and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Cyclin-dependent kinase-5 in neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

The calpains in aging and aging-related diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

The calpain system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

A "protease activation cascade" in the pathogenesis of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Calpain and caspase: can you tell the difference?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Subregion- and cell type-restricted gene knockout in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Calpain as a novel target for treating acute neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

The protease inhibitor leupeptin interferes with the development of LTP in hippocampal slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

5 July 2018

Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Calpain: a protease in search of a function?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

TRPC channels promote cerebellar granule neuron survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Dishevelled promotes axon differentiation by regulating atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Glycogen synthase kinase 3: a drug target for CNS therapies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.117960

21 January 2018

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

28 October 2018

Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

28 October 2018

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934641

28 October 2018

Possible role of calpain in normal processing of beta-amyloid precursor protein in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/20595388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient gene transfer into the embryonic mouse brain using in vivo electroporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20595388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

https://pubmed.ncbi.nlm.nih.gov/20595388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.117960

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595388%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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