(Q34107285)

31 July 2017

title

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C. (English)

1 reference

31 July 2017

author

Michelle S Parvatiyar

series ordinal

1

object named as

Michelle S Parvatiyar

1 reference

31 July 2017

Jose Renato Pinto

2

1 reference

31 July 2017

Jingsheng Liang

series ordinal

3

1 reference

31 July 2017

James D Potter

series ordinal

4

1 reference

31 July 2017

language of work or name

English

0 references

publication date

21 June 2010

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

285

1 reference

31 July 2017

issue

36

1 reference

31 July 2017

page(s)

27785-27797

1 reference

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Clinical and genetic issues in familial dilated cardiomyopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Troponin I, cardiac diastolic dysfunction and restrictive cardiomyopathy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Molecular and cellular aspects of troponin cardiomyopathies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Binding of levosimendan, a calcium sensitizer, to cardiac troponin C.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Biological function and site II Ca2+-induced opening of the regulatory domain of skeletal troponin C are impaired by invariant site I or II Glu mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Roles for the troponin tail domain in thin filament assembly and regulation. A deletional study of cardiac troponin T.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Calcium sensitising agents in heart failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

The effects of N helix deletion and mutant F29W on the Ca2+ binding and functional properties of chicken skeletal muscle troponin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

The effects of deletion of the amino-terminal helix on troponin C function and stability.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

A fluorescent probe study of Ca2+ binding to the Ca2+-specific sites of cardiac troponin and troponin C

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Thermodynamic study of domain organization in troponin C and calmodulin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilaments

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934646

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

In vitro motility analysis of thin filaments from failing and non-failing human heart: troponin from failing human hearts induces slower filament sliding and higher Ca(2+) sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Expanding the range of free calcium regulation in biological solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Effect of hydrophobic residue substitutions with glutamine on Ca(2+) binding and exchange with the N-domain of troponin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

The muscle thin filament as a classical cooperative/allosteric regulatory system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Energetics of the induced structural change in a Ca2+ regulatory protein: Ca2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Prevalence, Clinical Significance, and Genetic Basis of Hypertrophic Cardiomyopathy With Restrictive Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112326

Different functional properties of troponin T mutants that cause dilated cardiomyopathy

21 January 2018

1 reference

12 December 2020

Refinement of the structure of carp muscle calcium-binding parvalbumin by model building and difference fourier analysis

1 reference

12 December 2020

Chemically skinned mammalian skeletal muscle. I. The structure of skinned rabbit psoas

1 reference

12 December 2020

The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase

1 reference

12 December 2020

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1 reference

12 December 2020

Stimulation of cardiac myofilament force, ATPase activity and troponin C Ca++ binding by bepridil

1 reference

12 December 2020

Myocardial alpha-adrenoceptors and positive inotropy

1 reference

12 December 2020

The effect of [Mg2+] on the Ca2+ dependence of ATPase and tension development of fast skeletal muscle. The role of the Ca2+-specific sites of troponin C

1 reference

12 December 2020

Effect of rigor and cycling cross-bridges on the structure of troponin C and on the Ca2+ affinity of the Ca2+-specific regulatory sites in skinned rabbit psoas fibers

1 reference

12 December 2020

Increase by trifluoperazine in calcium sensitivity of myofibrils in a skinned fibre from frog skeletal muscle

1 reference

12 December 2020

Reciprocal coupling between troponin C and myosin crossbridge attachment

1 reference

12 December 2020

Construction and characterization of a spectral probe mutant of troponin C: application to analyses of mutants with increased calcium affinity

1 reference

12 December 2020

Troponin-C mutants with increased calcium affinity

1 reference

12 December 2020

A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction

1 reference

12 December 2020

Altered expression of troponin T isoforms in mild left ventricular hypertrophy in the rabbit

1 reference

12 December 2020

NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes

1 reference

12 December 2020

Regulatory properties of the NH2- and COOH-terminal domains of troponin T. ATPase activation and binding to troponin I and troponin C

1 reference

12 December 2020

Changes in intracellular Ca2+ mobilization and Ca2+ sensitization as mechanisms of action of physiological interventions and inotropic agents in intact myocardial cells

1 reference

12 December 2020

Fluorescence of NBD-labelled troponin-I as a probe for the kinetics of thin filament activation in skeletal muscle fibers

1 reference

12 December 2020

Modulation of cardiac troponin C function by the cardiac-specific N-terminus of troponin I: influence of PKA phosphorylation and involvement in cardiomyopathies

1 reference

12 December 2020

Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle

1 reference

12 December 2020

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

1 reference

12 December 2020

Calcium affinity of regulatory sites in skeletal troponin-C is attenuated by N-cap mutations of helix C

1 reference

12 December 2020

Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.112326

1 reference

31 July 2017

1 reference

31 July 2017

1 reference