(Q34127547)

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Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

scientific article published on September 2, 2010

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Europe PubMed Central

PubMed publication ID

31 July 2017

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model (English)

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Europe PubMed Central

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31 July 2017

Alzheimer's disease

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Fred van Leuven

7

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Fred Van Leuven

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31 July 2017

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An Tanghe

1

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Europe PubMed Central

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31 July 2017

Annelies Termont

2

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31 July 2017

Pascal Merchiers

3

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31 July 2017

Stephan Schilling

4

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31 July 2017

Hans-Ulrich Demuth

5

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Europe PubMed Central

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31 July 2017

Louise Scrocchi

6

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Europe PubMed Central

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31 July 2017

Gerard Griffioen

8

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Europe PubMed Central

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31 July 2017

Tom Van Dooren

9

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Europe PubMed Central

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31 July 2017

Fred Van Leuven

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20862386

18 July 2024

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18 July 2024

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2 September 2010

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31 July 2017

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15

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https://downloads.hindawi.com/journals/ijad/2010/417314.pdf

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18 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20862386/pdf/?tool=EBI

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18 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20862386/?tool=EBI

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18 July 2024

https://europepmc.org/articles/PMC2939388

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18 July 2024

https://europepmc.org/articles/PMC2939388?pdf=render

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18 July 2024

http://downloads.hindawi.com/journals/ijad/2010/417314.pdf

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10.4061/2010/417314

https://api.crossref.org/works/10.4061/2010/417314

18 July 2024

http://downloads.hindawi.com/journals/ijad/2010/417314.xml

1 reference

10.4061/2010/417314

https://api.crossref.org/works/10.4061/2010/417314

18 July 2024

International journal of Alzheimer's disease

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Europe PubMed Central

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31 July 2017

2010

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Europe PubMed Central

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31 July 2017

12816-12830

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Creative Commons Attribution 3.0 Unported

1 January 2010

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April 2022 Public Data File from Crossref

copyright status

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April 2022 Public Data File from Crossref

Alzheimer's disease: old problem, new views from transgenic and viral models

1 reference

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5 July 2018

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

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5 July 2018

Neuropathologic alterations in mild cognitive impairment: a review

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5 July 2018

Of mice and men: bridging the translational disconnect in CNS drug discovery

1 reference

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5 July 2018

Searching for new animal models of Alzheimer's disease.

1 reference

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5 July 2018

Epileptic seizures in AD patients

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5 July 2018

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

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5 July 2018

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

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5 July 2018

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

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5 July 2018

Classification and basic pathology of Alzheimer disease

1 reference

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5 July 2018

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

1 reference

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5 July 2018

Epilepsy and cognitive impairments in Alzheimer disease

1 reference

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5 July 2018

Mouse models of Alzheimer's dementia: current concepts and new trends

1 reference

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5 July 2018

Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications

1 reference

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5 July 2018

The value of incomplete mouse models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice

1 reference

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5 July 2018

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

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5 July 2018

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

1 reference

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5 July 2018

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939388

5 July 2018

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

1 reference

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

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Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

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Differences between vascular and plaque core amyloid in Alzheimer's disease

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Neuropathological stageing of Alzheimer-related changes

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

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Phases of A beta-deposition in the human brain and its relevance for the development of AD.

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Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage

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Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment.

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Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.

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The levels of cerebrospinal fluid Abeta40 and Abeta42(43) are regulated age-dependently.

1 reference

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Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

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Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

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Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20862386

12 December 2020

based on heuristic

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10.4061/2010/417314

https://api.crossref.org/works/10.4061/2010/417314

18 July 2024

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10.4061/2010/417314

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Europe PubMed Central

PubMed publication ID

31 July 2017

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1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

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31 July 2017

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