(Q34136545)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20822947%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Enzyme dynamics point to stepwise conformational selection in catalysis (English)

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13 February 2020

1

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13 February 2020

2

Ruth Nussinov

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13 February 2020

publication date

6 September 2010

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Current Opinion in Chemical Biology

13 February 2020

published in

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13 February 2020

volume

14

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13 February 2020

page(s)

652-659

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13 February 2020

issue

5

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Folding funnels and binding mechanisms

13 February 2020

cites work

1 reference

12 December 2020

Transition-state ensemble in enzyme catalysis: possibility, reality, or necessity?

1 reference

12 December 2020

Folding and binding cascades: dynamic landscapes and population shifts

1 reference

12 December 2020

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

1 reference

12 December 2020

Network of coupled promoting motions in enzyme catalysis

1 reference

12 December 2020

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase

1 reference

12 December 2020

Intrinsic dynamics of an enzyme underlies catalysis

1 reference

12 December 2020

Fluctuating enzymes: lessons from single-molecule studies.

1 reference

12 December 2020

Kramers model with a power-law friction kernel: dispersed kinetics and dynamic disorder of biochemical reactions.

1 reference

12 December 2020

The stability of monomeric intermediates controls amyloid formation: Abeta25-35 and its N27Q mutant

1 reference

12 December 2020

The dynamic energy landscape of dihydrofolate reductase catalysis

1 reference

12 December 2020

When does the Michaelis-Menten equation hold for fluctuating enzymes?

1 reference

12 December 2020

Ligand binding and circular permutation modify residue interaction network in DHFR.

1 reference

12 December 2020

A pre-equilibrium before nucleotide binding limits fingers subdomain closure by Klentaq1.

1 reference

12 December 2020

Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR

1 reference

12 December 2020

Intrinsic motions along an enzymatic reaction trajectory

1 reference

12 December 2020

Inhibitor-complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides

1 reference

12 December 2020

Dynamic personalities of proteins

1 reference

12 December 2020

Free-energy landscape of enzyme catalysis

1 reference

12 December 2020

Single molecule conformational dynamics of adenylate kinase: energy landscape, structural correlations, and transition state ensembles

1 reference

12 December 2020

Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach.

1 reference

12 December 2020

Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection

1 reference

12 December 2020

Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis.

1 reference

12 December 2020

Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase.

1 reference

12 December 2020

Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle

1 reference

12 December 2020

Atomic detail of chemical transformation at the transition state of an enzymatic reaction

1 reference

12 December 2020

Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase

1 reference

12 December 2020

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

1 reference

12 December 2020

Activation of the West Nile virus NS3 protease: Molecular dynamics evidence for a conformational selection mechanism

1 reference

12 December 2020

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

1 reference

12 December 2020

Snapshots of Dynamics in Synthesizing N 6 -Isopentenyladenosine at the tRNA Anticodon

1 reference

12 December 2020

Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4.

1 reference

12 December 2020

The hydrolysis activity of adenosine triphosphate in myosin: a theoretical analysis of anomeric effects and the nature of the transition state

1 reference

12 December 2020

Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate

1 reference

12 December 2020

The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.

1 reference

12 December 2020

Enzymatic transition states and dynamic motion in barrier crossing

1 reference

12 December 2020

Conformational selection or induced fit: a flux description of reaction mechanism

1 reference

12 December 2020

A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel

1 reference

12 December 2020

Role of conformational dynamics in kinetics of an enzymatic cycle in a nonequilibrium steady state.

1 reference

12 December 2020

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

1 reference

12 December 2020

The cluster of hydrophobic residues controls the entrance to the active site of choline oxidase.

1 reference

12 December 2020

Enzyme millisecond conformational dynamics do not catalyze the chemical step

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12 December 2020

Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.

1 reference

12 December 2020

Reversible chemical step and rate-limiting enzyme regeneration in the reaction catalyzed by formamidopyrimidine-DNA glycosylase.

1 reference

12 December 2020

Intrinsic domain and loop dynamics commensurate with catalytic turnover in an induced-fit enzyme.

1 reference

12 December 2020

The role of dynamic conformational ensembles in biomolecular recognition

1 reference

12 December 2020

Global conformational dynamics of a Y-family DNA polymerase during catalysis

1 reference

12 December 2020

Exploitation of binding energy for catalysis and design

1 reference

12 December 2020

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction

1 reference

12 December 2020

Reconciling the lock-and-key and dynamic views of canonical serine protease inhibitor action

1 reference

12 December 2020

Hidden alternative structures of proline isomerase essential for catalysis

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12 December 2020

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

1 reference

12 December 2020

Role of the RNA polymerase trigger loop in catalysis and pausing.

1 reference

12 December 2020

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

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12 December 2020

Conformational transitions in DNA polymerase I revealed by single-molecule FRET.

1 reference

12 December 2020

Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates

1 reference

12 December 2020

At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

1 reference

12 December 2020

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

1 reference

12 December 2020

Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase

1 reference

12 December 2020

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily

1 reference

12 December 2020

Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?

1 reference

12 December 2020

10.1016/J.CBPA.2010.08.012

Identifiers

DOI

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13 February 2020

1 reference

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13 February 2020

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