(Q34147023)

31 July 2017

title

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies (English)

1 reference

31 July 2017

main subject

traumatic brain injury

0 references

1

David J. Loane

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

17 August 2024

author name string

Alan I. Faden

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

17 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21035878

17 August 2024

publication date

29 October 2010

1 reference

full work available at URL

31 July 2017

https://europepmc.org/articles/pmc2999630?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21035878/pdf/?tool=EBI

17 August 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21035878/?tool=EBI

17 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

https://europepmc.org/articles/PMC2999630

17 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

https://europepmc.org/articles/PMC2999630?pdf=render

17 August 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

https://doi.org/10.1016/j.tips.2010.09.005

17 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21035878

Trends in Pharmacological Sciences

17 August 2024

published in

1 reference

31 July 2017

volume

31

1 reference

31 July 2017

issue

12

1 reference

31 July 2017

page(s)

596-604

1 reference

Progesterone in the clinical treatment of acute traumatic brain injury.

31 July 2017

cites work

1 reference

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IMPACT recommendations for improving the design and analysis of clinical trials in moderate to severe traumatic brain injury

5 July 2018

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Clinical trials in traumatic brain injury: past experience and current developments.

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Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury

5 July 2018

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5 July 2018

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Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion

5 July 2018

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The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI.

5 July 2018

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Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury

5 July 2018

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Combination therapies for traumatic brain injury: prospective considerations

5 July 2018

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Update of the stroke therapy academic industry roundtable preclinical recommendations

5 July 2018

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5 July 2018

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Multifunctional drug treatment in neurotrauma

5 July 2018

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Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage

5 July 2018

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Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury

5 July 2018

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Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury

5 July 2018

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Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758).

5 July 2018

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Moderate and severe traumatic brain injury in adults.

5 July 2018

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Classification of traumatic brain injury for targeted therapies

5 July 2018

1 reference

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Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

5 July 2018

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Efficacy of progesterone following a moderate unilateral cortical contusion injury

5 July 2018

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Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial

5 July 2018

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Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.

5 July 2018

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Drugs acting on SUR1 to treat CNS ischemia and trauma

5 July 2018

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Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog

5 July 2018

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Progesterone for the treatment of experimental brain injury; a systematic review

5 July 2018

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Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury

5 July 2018

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A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

5 July 2018

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Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature

5 July 2018

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5 July 2018

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The epidemiology and impact of traumatic brain injury: a brief overview

5 July 2018

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5 July 2018

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5 July 2018

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Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial

5 July 2018

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5 July 2018

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Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats

5 July 2018

1 reference

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Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury.

5 July 2018

1 reference

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Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

5 July 2018

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Recent progress in the discovery and development of cyclin-dependent kinase inhibitors

5 July 2018

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Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study

5 July 2018

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Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice

5 July 2018

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Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury.

5 July 2018

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Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats

5 July 2018

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Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation

5 July 2018

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

5 July 2018

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Clinical trials in head injury

5 July 2018

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Statins and neuroprotection

5 July 2018

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Use of statins in CNS disorders

5 July 2018

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Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats

5 July 2018

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Cyclin-dependent kinases as a therapeutic target for stroke.

5 July 2018

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Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone

5 July 2018

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Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury

5 July 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

5 July 2018

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Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury

5 July 2018

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Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

5 July 2018

1 reference

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Progesterone protects against lipid peroxidation following traumatic brain injury in rats

5 July 2018

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Characterization of diffuse axonal pathology and selective hippocampal damage following inertial brain trauma in the pig

5 July 2018

1 reference

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Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats

5 July 2018

1 reference

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Neuropathological sequelae of traumatic brain injury: relationship to neurochemical and biomechanical mechanisms

5 July 2018

1 reference

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Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats.

5 July 2018

1 reference

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The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A.

5 July 2018

1 reference

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Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells

5 July 2018

1 reference

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Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury

5 July 2018

1 reference

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Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway

28 October 2018

1 reference

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Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats.

28 October 2018

1 reference

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Progesterone improves acute recovery after traumatic brain injury in the aged rat.

28 October 2018

1 reference

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Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.

28 October 2018

1 reference

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Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury.

28 October 2018

1 reference

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Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.

28 October 2018

1 reference

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Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury

28 October 2018

1 reference

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Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats

28 October 2018

1 reference

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Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion

28 October 2018

1 reference

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Effects of progesterone on experimental spinal cord injury

28 October 2018

1 reference

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boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Role of the cell cycle in the pathobiology of central nervous system trauma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Neuroprotective effects of novel small peptides in vitro and after brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Novel small peptides with neuroprotective and nootropic properties

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Basis of progesterone protection in spinal cord neurodegeneration

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Behavioral responses of C57BL/6, FVB/N, and 129/SvEMS mouse strains to traumatic brain injury: implications for gene targeting approaches to neurotrauma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Gender-specific impairment on Morris water maze task after entorhinal cortex lesion.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Intracellular progesterone receptors are differentially regulated by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Treatment with thyrotropin-releasing hormone (TRH) in patients with traumatic spinal cord injuries

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2999630

Head injury in man and experimental animals: neuropathology

28 October 2018

1 reference

12 December 2020

Neuropathology of the vegetative state after head injury

1 reference

12 December 2020

NXY-059 for the treatment of acute ischemic stroke

1 reference

12 December 2020

Caspase-3 mediated neuronal death after traumatic brain injury in rats

1 reference

12 December 2020

10.1016/J.TIPS.2010.09.005

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference