(Q34147467)

31 July 2017

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title

How acute promyelocytic leukaemia revived arsenic (English)

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Valérie Lallemand-Breitenbach

31 July 2017

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4

Hugues de Thé

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series ordinal

3

object named as

Valérie Lallemand-Breitenbach

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31 July 2017

Jun Zhu

1

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31 July 2017

Zhu Chen

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 September 2002

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31 July 2017

Nature Reviews Cancer

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31 July 2017

2

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31 July 2017

705-713

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31 July 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc887

31 July 2017

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Acute promyelocytic leukemia

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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

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Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

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Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7

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Lineage restriction of the RARalpha gene expression in myeloid differentiation

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The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation

31 March 2020

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Positive and negative regulation of granulopoiesis by endogenous RARalpha

31 March 2020

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

31 March 2020

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

31 March 2020

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

31 March 2020

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

31 March 2020

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

31 March 2020

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SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

31 March 2020

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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

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Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy

31 March 2020

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PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

31 March 2020

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Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways

31 March 2020

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BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

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Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.

31 March 2020

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PML is essential for multiple apoptotic pathways

31 March 2020

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Role of PML in cell growth and the retinoic acid pathway

31 March 2020

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PML induces a novel caspase-independent death process

31 March 2020

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P53 and PML: new partners in tumor suppression

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PML, a growth suppressor disrupted in acute promyelocytic leukemia

31 March 2020

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

31 March 2020

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

31 March 2020

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The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

31 March 2020

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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

31 March 2020

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31 March 2020

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

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Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

31 March 2020

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Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide

31 March 2020

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Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

31 March 2020

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Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

31 March 2020

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Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

31 March 2020

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Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

31 March 2020

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Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia

31 March 2020

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Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

31 March 2020

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Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

31 March 2020

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Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

31 March 2020

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Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies

31 March 2020

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

31 March 2020

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The function of PML in p53-dependent apoptosis

31 March 2020

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Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

31 March 2020

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Arsenic inhibition of telomerase transcription leads to genetic instability

31 March 2020

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

31 March 2020

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The role of PML in tumor suppression

31 March 2020

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

31 March 2020

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SUMO, ubiquitin's mysterious cousin

31 March 2020

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

31 March 2020

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The nucleoporin RanBP2 has SUMO1 E3 ligase activity

31 March 2020

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The tripartite motif family identifies cell compartments

31 March 2020

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Regulation of Pax3 transcriptional activity by SUMO-1-modified PML

31 March 2020

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

31 March 2020

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Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

31 March 2020

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Modeling acute promyelocytic leukemia in the mouse: new insights in the pathogenesis of human leukemias

31 March 2020

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A sustained increase in the endogenous level of cAMP reduces the retinoid concentration required for APL cell maturation to near physiological levels.

31 March 2020

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Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC887

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Dimensions Publication ID

31 July 2017

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