(Q34154668)

31 July 2017

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title

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? (English)

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31 July 2017

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Edward H Koo

1

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31 July 2017

publication date

1 November 2002

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31 July 2017

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31 July 2017

volume

3

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31 July 2017

issue

11

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31 July 2017

page(s)

763-770

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

31 July 2017

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

21 January 2018

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What the evolution of the amyloid protein precursor supergene family tells us about its function

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Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

21 January 2018

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The role of presenilins in Alzheimer's disease

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease

21 January 2018

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Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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A common enzyme connects notch signaling and Alzheimer's disease

21 January 2018

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

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Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

21 January 2018

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Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

21 January 2018

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Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components

21 January 2018

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Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

21 January 2018

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Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

21 January 2018

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Role of the reelin signaling pathway in central nervous system development

21 January 2018

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Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

21 January 2018

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Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells

21 January 2018

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

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Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway

21 January 2018

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Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

21 January 2018

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

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Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

21 January 2018

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Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons

21 January 2018

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

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Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

21 January 2018

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Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

21 January 2018

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beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

21 January 2018

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Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein

21 January 2018

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

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Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Alzheimer's disease: genes, proteins, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31101.X

7 January 2021

10.1034/J.1600-0854.2002.31101.X

Identifiers

DOI

1 reference

31 July 2017

1 reference