(Q52546347)

3 May 2018

title

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. (English)

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3 May 2018

9

Erika L F Holzbaur

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author name string

Bernadette H LaMonte

1

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3 May 2018

Karen E Wallace

2

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3 May 2018

Beth A Holloway

3

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3 May 2018

Spencer S Shelly

4

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3 May 2018

Jennifer Ascaño

5

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3 May 2018

Mariko Tokito

6

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3 May 2018

Thomas Van Winkle

7

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3 May 2018

David S Howland

8

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3 May 2018

language of work or name

English

0 references

publication date

1 May 2002

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3 May 2018

published in

Neuron

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3 May 2018

volume

34

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3 May 2018

issue

5

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3 May 2018

page(s)

715-727

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3 May 2018

Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport.

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Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

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Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end

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Requirement of heavy neurofilament subunit in the development of axons with large calibers

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Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content

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Dynactin increases the processivity of the cytoplasmic dynein motor

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Cytoplasmic dynein conversion at a crush injury in rat peripheral axons

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7 January 2021

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport

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7 January 2021

Expression of the p150Glued component of the dynactin complex in developing and adult rat brain.

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Dynactin-Dependent, Dynein-Driven Vesicle Transport in the Absence of Membrane Proteins

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7 January 2021

Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin

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7 January 2021

ZW10 helps recruit dynactin and dynein to the kinetochore

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7 January 2021

Functionally distinct isoforms of dynactin are expressed in human neurons

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7 January 2021

Rapid movement of axonal neurofilaments interrupted by prolonged pauses

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7 January 2021

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)

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7 January 2021

The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

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7 January 2021

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

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7 January 2021

Subunit composition of neurofilaments specifies axonal diameter.

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7 January 2021

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

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7 January 2021

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

3 May 2018

1 reference

3 May 2018