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Antibiotics in the clinical pipeline in 2011.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Antibiotics in the clinical pipeline in 2011.
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
author
Mark S. Butler
object named as
Mark S Butler
series ordinal
1
0 references
Matthew A. Cooper
object named as
Matthew A Cooper
series ordinal
2
0 references
publication date
18 May 2011
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
published in
The Journal of Antibiotics
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
volume
64
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
issue
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
page(s)
413-425
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
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The antibacterial lead discovery challenge
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Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity.
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Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, bilogical and biochemical characterization.
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Lipiarmycin, a new antibiotic from Actinoplanes. I. Description of the producer strain and fermentation studies.
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Structure elucidation of the macrocyclic antibiotic lipiarmycin
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A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics
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Lipid II as a target for antibiotics
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Crossref
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7 January 2021
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A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface
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Crossref
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7 January 2021
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Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery
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Crossref
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7 January 2021
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Peptide deformylase as an antibacterial target: a critical assessment
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Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia
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In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models
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Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas
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Actinonin: an Antibiotic Substance produced by an Actinomycete
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Studies concerning the antibiotic actinonin. Part I. The constitution of actinonin. A natural hydroxamic acid with antibiotic activity
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Stieglitz rearrangement of N,N-dichloro-beta,beta-disubstituted taurines under mild aqueous conditions
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The diarylquinoline TMC207 for multidrug-resistant tuberculosis
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7 January 2021
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Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
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7 January 2021
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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
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7 January 2021
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Diarylquinolines target subunit c of mycobacterial ATP synthase
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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1 reference
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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1 reference
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7 January 2021
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1 reference
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Crossref
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7 January 2021
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7 January 2021
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7 January 2021
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7 January 2021
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
based on heuristic
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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7 January 2021
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7 January 2021
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis and mechanism of enoyl reductase inhibition by triclosan
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reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular basis of triclosan activity
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Crossref
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https://api.crossref.org/works/10.1038%2FJA.2011.44
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7 January 2021
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Triclosan-bacteria interactions: single or multiple target sites?
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A phase II study of antofloxacin hydrochloride, a novel fluoroquinolone, for the treatment of acute bacterial infections
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Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reductive alkylation of glycopeptide antibiotics: synthesis and antibacterial activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oritavancin: a novel lipoglycopeptide active against Gram-positive pathogens including multiresistant strains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oritavancin disrupts membrane integrity of Staphylococcus aureus and vancomycin-resistant enterococci to effect rapid bacterial killing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A comparative review of the lipoglycopeptides: oritavancin, dalbavancin, and telavancin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amides of de-acetylglucosaminyl-deoxy teicoplanin active against highly glycopeptide-resistant enterococci. Synthesis and antibacterial activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Origin, structure, and activity in vitro and in vivo of dalbavancin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Improved production of A40926 by Nonomuraea sp. through deletion of a pathway-specific acetyltransferase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cethromycin: a promising new ketolide antibiotic for respiratory infections
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ketolides--the modern relatives of macrolides : the pharmacokinetic perspective.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and spectrum of the neoglycoside ACHN-490
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combating evolution with intelligent design: the neoglycoside ACHN-490.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CEM-101 activity against Gram-positive organisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nitroimidazooxazines (PA-824 and analogs): structure-activity relationship and mechanistic studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PA-824 exhibits time-dependent activity in a murine model of tuberculosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro and bactericidal activities of ABT-492, a novel fluoroquinolone, against Gram-positive and Gram-negative organisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple-dose safety, tolerability, and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dihydrofolate reductase inhibitors as antibacterial agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multicenter, randomized study of the efficacy and safety of intravenous iclaprim in complicated skin and skin structure infections
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iclaprim, a novel diaminopyrimidine for the treatment of resistant gram-positive infections
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The challenge of new drug discovery for tuberculosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FJA.2011.44
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/JA.2011.44
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
Dimensions Publication ID
1022786044
0 references
PubMed publication ID
21587262
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21587262
retrieved
31 July 2017
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