(Q34190909)

English

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

drug interaction

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drug metabolism

1 reference

based on heuristic

inferred from title

author name string

Gian Camenisch

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Ken-ichi Umehara

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

publication date

19 April 2012

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Europe PubMed Central

PubMed publication ID

31 July 2017

Biopharmaceutics and Drug Disposition

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Europe PubMed Central

PubMed publication ID

31 July 2017

33

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Europe PubMed Central

PubMed publication ID

31 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

179-194

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

The roles of transporters and enzymes in hepatic drug processing

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Organ clearance concepts: new perspectives on old principles.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

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Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

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Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Quantitative prediction of intestinal metabolism in humans from a simplified intestinal availability model and empirical scaling factor

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

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Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Clinical pharmacokinetics of ciprofloxacin

1 reference

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In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Drug Metabolism and Drug Interactions: Application and Clinical Value of In Vitro Models

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Membrane transporters in drug development

1 reference

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Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin

1 reference

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Partial metabolic clearances as determinants of the oral bioavailability of propranolol

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Clinical pharmacokinetics of quinidine

1 reference

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21 January 2018

Clinical Pharmacology of Digitalis Glycosides

1 reference

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Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

1 reference

https://api.crossref.org/works/10.1002%2FBDD.1784

21 January 2018

Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism

1 reference

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21 January 2018

Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren

1 reference

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21 January 2018

Identifiers

10.1002/BDD.1784

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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