(Q34192072)

31 July 2017

1 reference

title

The Wnt signaling pathway and its role in tumor development (English)

1 reference

31 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707770

26 December 2023

repressor proteins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707770

26 December 2023

1 reference

https://api.crossref.org/works/10.1007/S00432-003-0431-0

26 December 2023

author name string

B. Lustig

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707770

26 December 2023

J. Behrens

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12707770

26 December 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12707770

26 December 2023

publication date

18 April 2003

1 reference

Journal of Cancer Research and Clinical Oncology

31 July 2017

1 reference

31 July 2017

129

1 reference

31 July 2017

199-221

1 reference

31 July 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1007/s00432-003-0431-0

31 July 2017

0 references

cites work

Beta-catenin and the morphogenesis of colorectal cancer

1 reference

12 December 2020

Beta-catenin mutations in cell lines established from human colorectal cancers

1 reference

12 December 2020

Recent advances in the molecular pathogenesis of lymphomas

1 reference

12 December 2020

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

1 reference

12 December 2020

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

1 reference

12 December 2020

Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis.

1 reference

12 December 2020

The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts

1 reference

12 December 2020

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

1 reference

12 December 2020

Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.

1 reference

12 December 2020

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

1 reference

12 December 2020

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

1 reference

12 December 2020

Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis

1 reference

12 December 2020

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

1 reference

12 December 2020

Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations

1 reference

12 December 2020

Tissue microarray-based analysis shows phospho-beta-catenin expression in malignant melanoma is associated with poor outcome

1 reference

12 December 2020

An HMG-box-containing T-cell factor required for thymocyte differentiation.

1 reference

12 December 2020

Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin

1 reference

12 December 2020

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC

1 reference

12 December 2020

beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis

1 reference

12 December 2020

Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1

1 reference

12 December 2020

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

1 reference

12 December 2020

Identification of a link between the tumour suppressor APC and the kinesin superfamily

1 reference

12 December 2020

PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2.

1 reference

12 December 2020

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

1 reference

12 December 2020

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

1 reference

12 December 2020

Identification of c-MYC as a target of the APC pathway

1 reference

12 December 2020

beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

1 reference

12 December 2020

Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

1 reference

12 December 2020

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

12 December 2020

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

1 reference

12 December 2020

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

1 reference

12 December 2020

Asef, a link between the tumor suppressor APC and G-protein signaling

1 reference

12 December 2020

Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.

1 reference

12 December 2020

Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor).

1 reference

12 December 2020

Wnt signaling controls the phosphorylation status of beta-catenin.

1 reference

12 December 2020

Mutations of the APC Gene in Human Sporadic Colorectal Cancers

1 reference

12 December 2020

APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.

1 reference

12 December 2020

Spindles cotton on to junctions, APC and EB1.

1 reference

12 December 2020

Association of the APC tumor suppressor protein with catenins

1 reference

12 December 2020

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

1 reference

12 December 2020

Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor.

1 reference

12 December 2020

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

1 reference

12 December 2020

Frodo interacts with Dishevelled to transduce Wnt signals

1 reference

12 December 2020

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction

1 reference

12 December 2020

Linking colorectal cancer to Wnt signaling

1 reference

12 December 2020

A common human skin tumour is caused by activating mutations in beta-catenin

1 reference

12 December 2020

Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.

1 reference

12 December 2020

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor

1 reference

12 December 2020

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

1 reference

12 December 2020

Analysis of beta-catenin gene mutations in pancreatic tumors

1 reference

12 December 2020

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1 reference

12 December 2020

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

1 reference

12 December 2020

The ins and outs of APC and beta-catenin nuclear transport

1 reference

12 December 2020

Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development

1 reference

12 December 2020

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene

1 reference

12 December 2020

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

1 reference

12 December 2020

beta-Catenin alteration in cancer of the ampulla of Vater

1 reference

12 December 2020

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification

1 reference

12 December 2020

Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations

1 reference

12 December 2020

1 reference

12 December 2020

Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis

1 reference

12 December 2020

Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.

1 reference

12 December 2020

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma

1 reference

12 December 2020

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

1 reference

12 December 2020

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

1 reference

12 December 2020

PML is a target gene of beta-catenin and plakoglobin, and coactivates beta-catenin-mediated transcription

1 reference

12 December 2020

Frequent association of beta-catenin and WT1 mutations in Wilms tumors.

1 reference

12 December 2020

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

1 reference

12 December 2020

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

1 reference

12 December 2020

Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas

1 reference

12 December 2020

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

1 reference

12 December 2020

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

1 reference

12 December 2020

Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin

1 reference

12 December 2020

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription

1 reference

12 December 2020

Wnt signaling and cancer

1 reference

12 December 2020

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

1 reference

12 December 2020

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin

1 reference

12 December 2020

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1 reference

12 December 2020

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

1 reference

12 December 2020

The subcellular destinations of APC proteins

1 reference

12 December 2020

Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice

1 reference

12 December 2020

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

12 December 2020

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

1 reference

12 December 2020

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

1 reference

12 December 2020

Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

12 December 2020

Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.

1 reference

12 December 2020

Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia

1 reference

12 December 2020

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

1 reference

12 December 2020

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

1 reference

12 December 2020

Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas

1 reference

12 December 2020

G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway.

1 reference

12 December 2020

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

12 December 2020

A new nuclear component of the Wnt signalling pathway

1 reference

12 December 2020

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas

1 reference

12 December 2020

Naked cuticle targets dishevelled to antagonize Wnt signal transduction

1 reference

12 December 2020

Wnt signalling: refocusing on Strabismus.

1 reference

12 December 2020

Attenuated familial adenomatous polyposis: an evolving and poorly understood entity

1 reference

12 December 2020

Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice

1 reference

12 December 2020

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

1 reference

12 December 2020

Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma

1 reference

12 December 2020

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

12 December 2020

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

12 December 2020

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

12 December 2020

Beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas

1 reference

12 December 2020

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

1 reference

12 December 2020

Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis.

1 reference

12 December 2020

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

12 December 2020

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

1 reference

12 December 2020

Automated subcellular localization and quantification of protein expression in tissue microarrays.

1 reference

12 December 2020

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors

1 reference

12 December 2020

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

1 reference

12 December 2020

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

1 reference

12 December 2020

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

1 reference

12 December 2020

Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells

1 reference

12 December 2020

APC mutations in sporadic medulloblastomas

1 reference

12 December 2020

Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia

1 reference

12 December 2020

The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis

1 reference

12 December 2020

Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients

1 reference

12 December 2020

Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors

1 reference

12 December 2020

Fecal DNA tests for colorectal cancer.

1 reference

12 December 2020

Wnt signaling: a common theme in animal development

1 reference

12 December 2020

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer

1 reference

12 December 2020

Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors

1 reference

12 December 2020

Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis

1 reference

12 December 2020

Down-regulation of beta-catenin by activated p53.

1 reference

12 December 2020

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

1 reference

12 December 2020

Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators

1 reference

12 December 2020

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

1 reference

12 December 2020

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

1 reference

12 December 2020

Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis

1 reference

12 December 2020

Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis

1 reference

12 December 2020

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.

1 reference

12 December 2020

Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours.

1 reference

12 December 2020

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1 reference

12 December 2020

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

1 reference

12 December 2020

A genetic model for colorectal tumorigenesis

1 reference

12 December 2020

Beta-catenin mutations in human prostate cancer.

1 reference

12 December 2020

Mutations in the APC tumour suppressor gene cause chromosomal instability

1 reference

12 December 2020

Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.

1 reference

12 December 2020

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin

1 reference

12 December 2020

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

1 reference

12 December 2020

Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway

1 reference

12 December 2020

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

1 reference

12 December 2020

beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

1 reference

12 December 2020

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

12 December 2020

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)

1 reference

12 December 2020

Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway

1 reference

12 December 2020

Top-down morphogenesis of colorectal tumors

1 reference

12 December 2020

Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.

1 reference

12 December 2020

Lessons from hereditary colorectal cancer

1 reference

12 December 2020

Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer

1 reference

12 December 2020

Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma

1 reference

12 December 2020

The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli

1 reference

12 December 2020

Linking beta-catenin to androgen-signaling pathway

1 reference

12 December 2020

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis

1 reference

12 December 2020

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

12 December 2020

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

1 reference

12 December 2020

Wnt signaling and dorso-ventral axis specification in vertebrates

1 reference

12 December 2020

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

12 December 2020

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

1 reference

12 December 2020

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer

1 reference

12 December 2020

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

1 reference

12 December 2020

Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells

1 reference

12 December 2020

Abnormalities of the APC/beta-catenin pathway in endometrial cancer

1 reference

12 December 2020

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

1 reference

12 December 2020

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

1 reference

12 December 2020

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

1 reference

12 December 2020

Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis

1 reference

12 December 2020

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

12 December 2020

beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.

1 reference

12 December 2020

WNT signaling and lymphocyte development

1 reference

12 December 2020

Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin

1 reference

12 December 2020

Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor

1 reference

12 December 2020

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

1 reference

12 December 2020

Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer

1 reference

12 December 2020

Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families

1 reference

12 December 2020

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

1 reference

12 December 2020

1 reference

12 December 2020

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

1 reference

12 December 2020

Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma

1 reference

12 December 2020

Casein kinase 2 associates with and phosphorylates dishevelled

1 reference

12 December 2020

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

1 reference

12 December 2020

Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer

1 reference

12 December 2020

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

1 reference

12 December 2020

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

1 reference

12 December 2020

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

1 reference

12 December 2020

Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland

1 reference

12 December 2020

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 reference

12 December 2020

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

1 reference

12 December 2020

Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon

1 reference

12 December 2020

Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma

1 reference

12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

1 reference

12 December 2020

Cancer, catenins, and cuticle pattern: a complex connection.

1 reference

12 December 2020

Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis

1 reference

12 December 2020

Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.

1 reference

12 December 2020

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity

1 reference

12 December 2020

Beckwith-Wiedemann syndrome, pancreatoblastoma, and the wnt signaling pathway

1 reference

12 December 2020

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

1 reference

12 December 2020

Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity

1 reference

12 December 2020

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice

1 reference

12 December 2020

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

1 reference

12 December 2020

APC binds to the novel protein EB1

1 reference

12 December 2020

Detection of APC mutations in fecal DNA from patients with colorectal tumors

1 reference

12 December 2020

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

12 December 2020

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

12 December 2020

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

1 reference

12 December 2020

Stabilization of beta-catenin by genetic defects in melanoma cell lines

1 reference

12 December 2020

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization

1 reference

12 December 2020

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

1 reference

12 December 2020

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

1 reference

12 December 2020

Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

1 reference

12 December 2020

Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p

1 reference

12 December 2020

T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis.

1 reference

12 December 2020

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

1 reference

12 December 2020

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

1 reference

12 December 2020

beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome

1 reference

12 December 2020

AXIN1 mutations but not deletions in cerebellar medulloblastomas.

1 reference

12 December 2020

Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor

1 reference

12 December 2020

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

12 December 2020

Identification of FAP locus genes from chromosome 5q21

1 reference

12 December 2020

TCF transcription factors, mediators of Wnt-signaling in development and cancer

1 reference

12 December 2020

Detection and analysis of beta-catenin mutations in prostate cancer

1 reference

12 December 2020

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

1 reference

12 December 2020

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

1 reference

12 December 2020

Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma

1 reference

12 December 2020

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

1 reference

12 December 2020

Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

1 reference

12 December 2020

TCF transcription factors: molecular switches in carcinogenesis

1 reference

12 December 2020

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1 reference

12 December 2020

Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells

1 reference

12 December 2020

Excess beta-catenin promotes accumulation of transcriptionally active p53.

1 reference

12 December 2020

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

1 reference

12 December 2020

A Drosophila APC tumour suppressor homologue functions in cellular adhesion

1 reference

12 December 2020

A repeating amino acid motif shared by proteins with diverse cellular roles

1 reference

12 December 2020

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

1 reference

12 December 2020

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

1 reference

12 December 2020

Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.

1 reference

12 December 2020

Mutations in exon 3 of the β-catenin gene are rare in melanoma cell lines

1 reference

12 December 2020

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

1 reference

12 December 2020

Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study

1 reference

12 December 2020

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

12 December 2020

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

12 December 2020

Inflating cell numbers by Wnt.

1 reference

12 December 2020

Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q

1 reference

12 December 2020

Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas

1 reference

12 December 2020

Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma

1 reference

12 December 2020

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

1 reference

12 December 2020

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

12 December 2020

Acetylation of beta-catenin by CREB-binding protein (CBP).

1 reference

12 December 2020

CRM1- and Ran-independent nuclear export of beta-catenin.

1 reference

12 December 2020

Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma

1 reference

12 December 2020

APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers

1 reference

12 December 2020

A transcriptional response to Wnt protein in human embryonic carcinoma cells

1 reference

12 December 2020

Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin

144

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00432-003-0431-0

Culprits in the degradation of cyclin E apprehended

26 December 2023

244

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00432-003-0431-0

26 December 2023

Identifiers

DOI

0 references

1 reference