(Q34193142)

31 July 2017

title

The tempered polymerization of human neuroserpin (English)

1 reference

31 July 2017

9

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31 July 2017

Maria Rosalia Mangione

Maria Rosalia Mangione

4

0 references

Mauro Manno

Mauro Manno

10

0 references

Matteo Levantino

Matteo Levantino

5

0 references

Vincenzo Martorana

Vincenzo Martorana

7

0 references

Stefano Ricagno

Stefano Ricagno

3

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author name string

Rosina Noto

1

1 reference

31 July 2017

Maria Grazia Santangelo

2

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31 July 2017

Margherita Pezzullo

6

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31 July 2017

Antonio Cupane

8

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31 July 2017

language of work or name

English

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publication date

6 March 2012

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31 July 2017

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31 July 2017

volume

7

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31 July 2017

issue

3

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31 July 2017

page(s)

e32444

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Creative Commons Attribution 4.0 International

31 July 2017

copyright license

start time

6 March 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

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Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization

5 July 2018

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Two latent and two hyperstable polymeric forms of human neuroserpin

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Defining the mechanism of polymerization in the serpinopathies

5 July 2018

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A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

5 July 2018

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An analytical solution to the kinetics of breakable filament assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Fibril fragmentation enhances amyloid cytotoxicity

5 July 2018

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Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin.

5 July 2018

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Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Human neuroserpin: structure and time-dependent inhibition

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Conformational pathology of the serpins: themes, variations, and therapeutic strategies

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Branching in amyloid fibril growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

The structural basis of serpin polymerization studied by hydrogen/deuterium exchange and mass spectrometry

5 July 2018

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Revisiting the method of cumulants for the analysis of dynamic light-scattering data

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

5 July 2018

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Molecular gymnastics: serpin structure, folding and misfolding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation

5 July 2018

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Neuroserpin: a serpin to think about

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies

5 July 2018

1 reference

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Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

How do proteins avoid becoming too stable? Biophysical studies into metastable proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Serpin structure, mechanism, and function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Association between conformational mutations in neuroserpin and onset and severity of dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Structure of a serpin-protease complex shows inhibition by deformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Universal Aging Features in the Restructuring of Fractal Colloidal Gels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Familial dementia caused by polymerization of mutant neuroserpin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

5 July 2018

Conformational disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Theoretical studies on oscillations in microtubule polymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Synchronous oscillations in microtubule polymerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

Molecular bases of neuroserpin function and pathology.

5 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

On the molecular structure of human neuroserpin polymers.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Alpha 1-antitrypsin polymerization: a fluorescence correlation spectroscopic study.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Moment analysis of the cluster-size-distribution approach to scaling during coagulation.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Analysis of protein aggregation kinetics.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3295756

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

28 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Kinetics of Different Processes in Human Insulin Amyloid Formation

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032444

Existence of metastable intermediate lysozyme conformation highlights the role of alcohols in altering protein stability

21 January 2018

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12 December 2020

A model of microtubule oscillations

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12 December 2020

Variable aggregation rates in colloidal gold: Kernel homogeneity dependence on aggregant concentration

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12 December 2020

Cluster-size evolution in a coagulation-fragmentation system

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12 December 2020

10.1371/JOURNAL.PONE.0032444

Identifiers

DOI

1 reference

31 July 2017

0 references

1 reference

31 July 2017

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