(Q41943843)

14 October 2017

Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization (English)

1 reference

14 October 2017

Beena Krishnan

1

1 reference

PMC publication ID

3074950

14 October 2017

Lila M Gierasch

series ordinal

2

1 reference

14 October 2017

23 January 2011

1 reference

Nature Structural & Molecular Biology

14 October 2017

1 reference

14 October 2017

18

1 reference

14 October 2017

2

1 reference

14 October 2017

222-226

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.1976

14 October 2017

0 references

cites work

Defining the mechanism of polymerization in the serpinopathies

1 reference

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Loop-Sheet Mechanism of Serpin Polymerization Tested by Reactive Center Loop Mutations

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

An introduction to methods for analyzing thiols and disulfides: Reactions, reagents, and practical considerations

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Biochemical properties of plasminogen activator inhibitor-1.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Conformational pathology of the serpins: themes, variations, and therapeutic strategies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

A1ATVar: a relational database of human SERPINA1 gene variants leading to alpha1-antitrypsin deficiency and application of the VariVis software

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.

5 June 2018

1 reference

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Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Latent antithrombin and its detection, formation and turnover in the circulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Serpin structure, mechanism, and function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Structure of a serpin-protease complex shows inhibition by deformation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Probing the unfolding pathway of alpha1-antitrypsin.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

New insights into the structural basis of alpha 1-antitrypsin deficiency

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Reexamination of the folding of BPTI: predominance of native intermediates.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Probing the role of the F-helix in serpin stability through a single tryptophan substitution

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Pegylation: a method for assessing topological accessibilities in Kv1.3.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

The folding of alpha-1-proteinase inhibitor: kinetic vs equilibrium control

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

Perturbation of a tertiary hydrogen bond in barstar by mutagenesis of the sole His residue to Gln leads to accumulation of at least one equilibrium folding intermediate.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074950

18 August 2018

Serpins' mystery solved

1 reference

α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

21 January 2018

1 reference

Kinetically controlled folding of the serpin plasminogen activator inhibitor 1

21 January 2018

1 reference

Cooperative unfolding of a metastable serpin to a molten globule suggests a link between functional and folding energy landscapes

31 March 2020

1 reference

Distribution of the native strain in human alpha 1-antitrypsin and its association with protease inhibitor function

31 March 2020

1 reference

Effects of glycosylation on the folding and stability of human, recombinant and cleaved alpha 1-antitrypsin

31 March 2020

1 reference

Repair of the secretion defect in the Z form of alpha 1-antitrypsin by addition of a second mutation

31 March 2020

1 reference

A thermostable mutation located at the hydrophobic core of alpha 1-antitrypsin suppresses the folding defect of the Z-type variant

31 March 2020

1 reference

Rare alpha 1 antitrypsin allele PI W and a history of infant liver disease

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.1976

1 reference

14 October 2017

1 reference

PMC publication ID

3074950

14 October 2017

PubMed publication ID

21258324

1 reference

PMC publication ID

3074950