(Q34200930)

31 July 2017

title

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. (English)

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31 July 2017

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13

Carine Michiels

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Suveera Dhup

Suveera Dhup

8

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Pierre Danhier

Pierre Danhier

9

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Frédérique Végran

Frédérique Végran

4

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Pierre Sonveaux

Pierre Sonveaux

1

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Olivier Feron

15

Olivier Feron

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31 July 2017

11

Bernard Gallez

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Christophe J De Saedeleer

31 July 2017

3

Christophe J De Saedeleer

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31 July 2017

2

Tamara Copetti

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31 July 2017

5

Julien Verrax

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31 July 2017

Kelly M Kennedy

6

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31 July 2017

Eui Jung Moon

7

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31 July 2017

Françoise Frérart

10

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31 July 2017

Anthony Ribeiro

12

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31 July 2017

Mark W Dewhirst

14

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31 July 2017

language of work or name

English

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publication date

13 March 2012

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31 July 2017

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31 July 2017

volume

7

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31 July 2017

issue

3

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31 July 2017

page(s)

e33418

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Creative Commons Attribution 4.0 International

31 July 2017

copyright license

start time

13 March 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

5 July 2018

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On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives.

5 July 2018

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HIF-1: upstream and downstream of cancer metabolism

5 July 2018

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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

5 July 2018

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Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.

5 July 2018

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Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

5 July 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

5 July 2018

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Regulation of angiogenesis by oxygen and metabolism.

5 July 2018

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

5 July 2018

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5 July 2018

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Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor

5 July 2018

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5 July 2018

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HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

5 July 2018

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Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms

5 July 2018

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Regulation of HIF-1alpha stability through S-nitrosylation

5 July 2018

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Mitochondria as signaling organelles in the vascular endothelium

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease

5 July 2018

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Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Akt stimulates aerobic glycolysis in cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Targeting HIF-1 for cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Regulation of angiogenesis by hypoxia: role of the HIF system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Mouse aortic ring assay: A new approach of the molecular genetics of angiogenesis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model

5 July 2018

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

5 July 2018

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Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

5 July 2018

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Angiogenesis in cancer and other diseases

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Microvascular studies on the origins of perfusion-limited hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Establishment of a cloned line of Lewis lung carcinoma cells adapted to cell culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302812

Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Comparison of methods for measuring oxygen consumption in tumor cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033418

Inhibition of glucose oxidation by alpha-cyano-4-hydroxycinnamic acid stimulates feeding in rats

21 January 2018

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Collagen and Cell Protein Synthesis by an Established Mammalian Fibroblast Line

21 January 2018

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A new transplantable mouse liver tumor of spontaneous origin

21 January 2018

1 reference

12 December 2020

Oxamate as a Differential Inhibitor of Lactate Dehydrogenase Isoenzymes

1 reference

12 December 2020

Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery

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12 December 2020

Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy

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12 December 2020

Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy

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Influence of enzymatic phospholipid cleavage on the permeability of the erythrocyte membrane. II. Protein-mediated transfer of monosaccharides and anions

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12 December 2020

Regulatory mechanisms in carbohydrate metabolism. IV. Pasteur effect and Crabtree effect in ascites tumor cells

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12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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12 December 2020

10.1371/JOURNAL.PONE.0033418

Identifiers

DOI

1 reference

31 July 2017

0 references

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31 July 2017

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