(Q34202564)

25069035

31 July 2017

title

Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol (English)

1 reference

31 July 2017

0 references

Alexandros G Georgakilas

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Christophe E Redon

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Nicholas F Ferguson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Thomas B Kryston

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Palak Parekh

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Jennifer S Dickey

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Asako J Nakamura

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

James B Mitchell

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

William M Bonner

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Olga A Martin

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

25 July 2014

1 reference

31 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

353

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

248-257

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.

31 May 2020

cites work

1 reference

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Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model

5 July 2018

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Induction and repair of clustered DNA lesions: what do we know so far?

5 July 2018

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Role of Renin-Angiotensin system and oxidative stress on vascular inflammation in insulin resistence model

5 July 2018

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Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.

5 July 2018

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The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

5 July 2018

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CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells

5 July 2018

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5 July 2018

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Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

5 July 2018

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Pharmacological protection from radiation ± cisplatin-induced oral mucositis

5 July 2018

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The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity

5 July 2018

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5 July 2018

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Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

5 July 2018

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A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector

5 July 2018

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Camouflage and sabotage: tumor escape from the immune system

5 July 2018

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Systemic DNA damage related to cancer

5 July 2018

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Para-inflammation mediates systemic DNA damage in response to tumor growth

5 July 2018

1 reference

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Role of oxidative stress and DNA damage in human carcinogenesis

5 July 2018

1 reference

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Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing.

5 July 2018

1 reference

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Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape

5 July 2018

1 reference

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Tumors induce complex DNA damage in distant proliferative tissues in vivo

5 July 2018

1 reference

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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

5 July 2018

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Quantitative measurement of reactive oxygen species in vivo by utilizing a novel method: chemiluminescence with an internal fluorescence as reference

5 July 2018

1 reference

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Radioprotectors and mitigators of radiation-induced normal tissue injury

5 July 2018

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Metastasis: cancer cell's escape from oxidative stress.

5 July 2018

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BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions.

5 July 2018

1 reference

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Genomic instability--an evolving hallmark of cancer

5 July 2018

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Role of oxidatively induced DNA lesions in human pathogenesis

5 July 2018

1 reference

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Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation

5 July 2018

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FociCounter: a freely available PC programme for quantitative and qualitative analysis of gamma-H2AX foci.

5 July 2018

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Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.

5 July 2018

1 reference

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Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells

5 July 2018

1 reference

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H2AX: functional roles and potential applications

5 July 2018

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Intercellular communication of cellular stress monitored by gamma-H2AX induction

5 July 2018

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Radiation-induced bystander signalling in cancer therapy

5 July 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

5 July 2018

1 reference

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Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

5 July 2018

1 reference

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5 July 2018

1 reference

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ATM acts downstream of ATR in the DNA damage response signaling of bystander cells

5 July 2018

1 reference

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Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum

5 July 2018

1 reference

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Cancer-related inflammation

5 July 2018

1 reference

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Activation of the cellular DNA damage response in the absence of DNA lesions

5 July 2018

1 reference

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Formation of clustered DNA damage after high-LET irradiation: a review

5 July 2018

1 reference

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

5 July 2018

1 reference

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Processing of DNA damage clusters in human cells: current status of knowledge

5 July 2018

1 reference

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Detection of complex DNA damage in gamma-irradiated acute lymphoblastic leukemia Pre-b NALM-6 cells

5 July 2018

1 reference

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gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication

5 July 2018

1 reference

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Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells.

5 July 2018

1 reference

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DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models

5 July 2018

1 reference

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The chemistry and biology of nitroxide compounds

5 July 2018

1 reference

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Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells

5 July 2018

1 reference

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Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice

5 July 2018

1 reference

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Dual role of macrophages in tumor growth and angiogenesis

5 July 2018

1 reference

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Cellular radiation effects and the bystander response

5 July 2018

1 reference

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Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway

5 July 2018

1 reference

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Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

The death-inducing effect and genomic instability.

5 July 2018

1 reference

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Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Endogenous DNA damage in humans: a review of quantitative data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Histone H2AX in DNA damage and repair.

5 July 2018

1 reference

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Radical causes of cancer.

5 July 2018

1 reference

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Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Persistent oxidative stress in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Production of large amounts of hydrogen peroxide by human tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Topical application of nitroxide protects radiation-induced alopecia in guinea pigs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Oral exfoliative cytology for the diagnosis of paracoccidoidomycosis in a patient with human immunodeficiency virus: a case report

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

The superoxide dismutase mimetic, tempol, blunts right ventricular hypertrophy in chronic hypoxic rats.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

A low molecular weight antioxidant decreases weight and lowers tumor incidence

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

Protection from radiation-induced alopecia with topical application of nitroxides: fractionated studies

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167057

In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG-triggered 3D time-resolved magnetic resonance angiography

28 October 2018

1 reference

12 December 2020

Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells

1 reference

12 December 2020

In vitro protection of vascular function from oxidative stress and inflammation by pulsatility in resistance arteries

1 reference

12 December 2020

In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen

1 reference

12 December 2020

TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol

1 reference

12 December 2020

Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo

1 reference

12 December 2020

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

1 reference

12 December 2020

Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage

1 reference

12 December 2020

10.1016/J.CANLET.2014.07.030

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

release_7zcdbaeplzg6npydig3imqr5pe

31 May 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7zcdbaeplzg6npydig3imqr5pe

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

25069035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069035%20AND%20SRC:MED&resulttype=core&format=json