(Q34206832)

30 June 2019

title

Novel approaches to flavivirus drug discovery (English)

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30 June 2019

1 reference

2

Richard J Kuhn

1 reference

PubMed publication ID

31 July 2017

Carolyn Botting

1

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30 June 2019

language of work or name

English

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publication date

22 March 2012

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30 June 2019

Expert Opinion on Drug Discovery

published in

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30 June 2019

volume

7

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30 June 2019

issue

5

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30 June 2019

page(s)

417-428

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30 June 2019

Better late than never: antivirals for dengue

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Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

21 January 2018

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Recent advances in flavivirus antiviral drug discovery and vaccine development

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Morphogenesis of yellow fever virus 17D in infected cell cultures

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Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

21 January 2018

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Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation

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A ligand-binding pocket in the dengue virus envelope glycoprotein

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The membrane-active regions of the dengue virus proteins C and E.

21 January 2018

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Stable expression of noncytopathic Kunjin replicons simulates both ultrastructural and biochemical characteristics observed during replication of Kunjin virus

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21 January 2018

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21 January 2018

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Virus attachment and entry offer numerous targets for antiviral therapy

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Identification of novel target sites and an inhibitor of the dengue virus E protein

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Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein

21 January 2018

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In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses.

21 January 2018

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Structural optimization and de novo design of dengue virus entry inhibitory peptides

21 January 2018

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21 January 2018

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21 January 2018

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Antibacterial agents based on the cyclic D,L-alpha-peptide architecture

21 January 2018

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A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and E. coli and the biofouling algae Ulva linza and Navicula perminuta

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

RNA interference inhibits replication of tick-borne encephalitis virus in vitro

21 January 2018

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RNA interference inhibits yellow fever virus replication in vitro and in vivo

21 January 2018

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Countering hepatitis B virus infection using RNAi: how far are we from the clinic?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Identification of natural compounds with antiviral activities against SARS-associated coronavirus

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Effect of alkaloids isolated from Amaryllidaceae on herpes simplex virus

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2',5'-oligoadenylate synthetase 1b.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Inhibition of dengue virus by targeting viral NS4B protein

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Inhibition of West Nile virus replication in cells stably transfected with vector-based shRNA expression system

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Capsid-targeted viral inactivation can destroy dengue 2 virus from within in vitro

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virus.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Uptake and metabolism of BuCast: a glycoprotein processing inhibitor and a potential anti-HIV drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Modification of intracellular membrane structures for virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Quantitative Analysis of the Hepatitis C Virus Replication Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.673579

Plant antiviral agents. III. Isolation of alkaloids from Clivia miniata Regel (Amaryllidaceae)

21 January 2018

1 reference

12 December 2020

Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E

1 reference

12 December 2020

6-Epicastanospermine, a novel indolizidine alkaloid that inhibits alpha-glucosidase

1 reference

12 December 2020

Clickable functionalization of liposomes with the gH625 peptide from Herpes simplex virus type I for intracellular drug delivery

1 reference

12 December 2020

Proteolytic activation of tick-borne encephalitis virus by furin

1 reference

12 December 2020

Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein

1 reference

12 December 2020

10.1517/17460441.2012.673579

Identifiers

DOI

1 reference

30 June 2019

PMC publication ID

6190671

1 reference

30 June 2019

PubMed publication ID

22439769

1 reference

30 June 2019