(Q37931159)

25 August 2017

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title

Countering hepatitis B virus infection using RNAi: how far are we from the clinic? (English)

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25 August 2017

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Dejana Ivacik

1

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25 August 2017

Abdullah Ely

series ordinal

2

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25 August 2017

Patrick Arbuthnot

series ordinal

3

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25 August 2017

publication date

13 September 2011

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Reviews in Medical Virology

25 August 2017

published in

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25 August 2017

volume

21

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25 August 2017

issue

6

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25 August 2017

page(s)

383-396

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

25 August 2017

cites work

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Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma

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RNAi for treating hepatitis B viral infection

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Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection.

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Hepatitis B virus replication

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Hepatitis B virus and hepatocellular carcinoma

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21 January 2018

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Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles

21 January 2018

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Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells

21 January 2018

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Regulatory elements of hepatitis B virus transcription

21 January 2018

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Biochemical and genetic evidence for the hepatitis B virus replication strategy

21 January 2018

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MicroRNA biogenesis: coordinated cropping and dicing

21 January 2018

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Small non-coding RNAs in animal development

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

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Single processing center models for human Dicer and bacterial RNase III

21 January 2018

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

21 January 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

21 January 2018

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

21 January 2018

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The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Effective expression of small interfering RNA in human cells

21 January 2018

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Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs

21 January 2018

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Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

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Inhibition of hepatitis B virus expression and replication by RNA interference

21 January 2018

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Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs

21 January 2018

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Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

21 January 2018

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Small interfering RNA Inhibits Hepatitis B virus replication in mice

21 January 2018

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Short interfering RNA-directed inhibition of hepatitis B virus replication

21 January 2018

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Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

21 January 2018

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A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

21 January 2018

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Defining the optimal parameters for hairpin-based knockdown constructs

21 January 2018

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Optimization of shRNA inhibitors by variation of the terminal loop sequence

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Reduced seed region-based off-target activity with lentivirus-mediated RNAi

21 January 2018

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Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

21 January 2018

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

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A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

21 January 2018

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Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

21 January 2018

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

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Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

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Optimization and characterization of tRNA-shRNA expression constructs

21 January 2018

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tRNA Lys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs

21 January 2018

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Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles

21 January 2018

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Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo

21 January 2018

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Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

21 January 2018

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Vector design for liver-specific expression of multiple interfering RNAs that target hepatitis B virus transcripts

21 January 2018

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Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

21 January 2018

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Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

21 January 2018

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Infection of a human hepatoma cell line by hepatitis B virus

21 January 2018

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The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

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Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

21 January 2018

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Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection

21 January 2018

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Efficient inhibition of hepatitis B virus replication in vivo, using polyethylene glycol-modified adenovirus vectors

21 January 2018

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Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice

21 January 2018

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Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

21 January 2018

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The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV.

21 January 2018

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The woodchuck model of hepatitis B virus infection

21 January 2018

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21 January 2018

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Transmission of Type B Viral Hepatitis to Chimpanzees

21 January 2018

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Hepatic delivery of RNA interference activators for therapeutic application

21 January 2018

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Adenovirus serotype 5 hexon mediates liver gene transfer

21 January 2018

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Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators

21 January 2018

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Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector

21 January 2018

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PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile

21 January 2018

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The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver

21 January 2018

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

21 January 2018

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Adeno-associated virus serotypes: vector toolkit for human gene therapy

21 January 2018

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From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

21 January 2018

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Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA.

21 January 2018

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Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9.

21 January 2018

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A phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C adeno-associated virus vaccine

21 January 2018

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

21 January 2018

1 reference

Lentiviral vectors for anti-tumor immunotherapy.

21 January 2018

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Mechanisms governing lentivirus integration site selection

21 January 2018

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Strategies for targeting lentiviral vectors

21 January 2018

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Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

21 January 2018

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Non-integrating lentiviral vectors.

21 January 2018

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Clinical application of lentiviral vectors - concepts and practice

21 January 2018

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Development and applications of non-HIV-based lentiviral vectors in neurological disorders

21 January 2018

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Efficient lentiviral transduction of liver requires cell cycling in vivo

21 January 2018

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RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

21 January 2018

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Gene transfer in humans using a conditionally replicating lentiviral vector

21 January 2018

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Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat.

21 January 2018

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Ex vivo hepatocyte gene therapy: increased biosafety protocol for transduction in suspension with lentiviral vectors and immediate transplantation (SLIT).

21 January 2018

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Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates

21 January 2018

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A step toward liver gene therapy: efficient correction of the genetic defect of hepatocytes isolated from a patient with Crigler-Najjar syndrome type 1 with lentiviral vectors.

21 January 2018

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Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

21 January 2018

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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.

21 January 2018

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Physicochemical parameters of non-viral vectors that govern transfection efficiency

21 January 2018

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Muscular gene transfer using nonviral vectors

21 January 2018

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Sustained transgene expression using MAR elements

21 January 2018

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Polymer-based gene delivery: a current review on the uptake and intracellular trafficking of polyplexes.

21 January 2018

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Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example

21 January 2018

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Sustained transgene expression using non-viral enzymatic systems for stable chromosomal integration.

21 January 2018

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Extracellular targeting of synthetic therapeutic nucleic acid formulations

21 January 2018

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Convergence of opposite sciences for the future development of non viral gene therapy

21 January 2018

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Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery

21 January 2018

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Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection.

21 January 2018

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siRNA delivery to CNS cells using a membrane translocation peptide

21 January 2018

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Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi.

21 January 2018

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Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity

21 January 2018

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Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3'-terminus

21 January 2018

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Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles

21 January 2018

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Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I.

21 January 2018

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Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection

21 January 2018

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Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways

21 January 2018

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Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/RMV.705

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25 August 2017

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