(Q34242480)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Biosynthesis of 3,5-AHBA-derived natural products (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

3-amino-5-hydroxybenzoic acid

19 January 2020

main subject

1 reference

ChEBI release 2020-05-28

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Qianjin Kang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Linquan Bai

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

publication date

22 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

published in

Natural Product Reports

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

243-263

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22193711%20AND%20SRC:MED&resulttype=core&format=json

Effect of rifamycin on protein synthesis

19 January 2020

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Mitomycin C: small, fast and deadly (but very selective)

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Geldanamycin and its anti-cancer activities

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Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

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Natural products derived from unusual variants of the shikimate pathway

21 January 2018

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The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.

21 January 2018

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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

21 January 2018

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Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate.

21 January 2018

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Biosynthesis of 1-deoxy-1-imino-D-erythrose 4-phosphate: a defining metabolite in the aminoshikimate pathway

21 January 2018

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3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.

21 January 2018

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Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase

21 January 2018

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Selective isolation and ansamycin-targeted screenings of commensal actinomycetes from the "maytansinoids-producing" arboreal Trewia nudiflora

21 January 2018

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Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants.

21 January 2018

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History of the Development of Rifampin

21 January 2018

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Rifamycin-mode of action, resistance, and biosynthesis

21 January 2018

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Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061.

21 January 2018

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Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.

21 January 2018

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Cloning and analysis of DNA sequences from Streptomyces hygroscopicus encoding geldanamycin biosynthesis

21 January 2018

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Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

21 January 2018

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Transcriptome mining of active biosynthetic pathways and their associated products in Streptomyces flaveolus

21 January 2018

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Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors

21 January 2018

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Mitomycin: clinical applications in ophthalmic practice

21 January 2018

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Structure-activity relationships for mitomycin C and mitomycin A analogues

21 January 2018

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Hygrocins a and B, naphthoquinone macrolides from Streptomyces hygroscopicus

21 January 2018

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Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit

21 January 2018

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Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp.

21 January 2018

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Leprosy. Recognition and treatment

21 January 2018

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From ergot to ansamycins-45 years in biosynthesis

21 January 2018

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Lessons from the rifamycin biosynthetic gene cluster

21 January 2018

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The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates

21 January 2018

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The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products

21 January 2018

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A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line

21 January 2018

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Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.

21 January 2018

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Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.

21 January 2018

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Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450.

21 January 2018

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Rubradirin, an inhibitor of ribosomal polypeptide biosynthesis

21 January 2018

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Rubradirin, a selective inhibitor of initiation factor dependent peptide-chain initiation

21 January 2018

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Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains

21 January 2018

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Functional identification of rub52 gene involved in the biosynthesis of rubradirin.

21 January 2018

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Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris.

21 January 2018

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A unifying nitrososynthase involved in nitrosugar biosynthesis

21 January 2018

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Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892.

21 January 2018

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Letter: Protostreptovaricins I-V

21 January 2018

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Carbon-13 magnetic resonance spectroscopy and the biosynthesis of streptovaricin

21 January 2018

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Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption

21 January 2018

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Novel lipoxygenase inhibitors, tetrapetalone B, C, and D from Streptomyces sp.

21 January 2018

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The ansacarbamitocins: polar ansamitocin derivatives

21 January 2018

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Recent developments in the maytansinoid antitumor agents

21 January 2018

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Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis

21 January 2018

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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

21 January 2018

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Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum

21 January 2018

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Chemoenzymatic approaches toward dechloroansamitocin P-3.

21 January 2018

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Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.

21 January 2018

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Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst

21 January 2018

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Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.

21 January 2018

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N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis

21 January 2018

1 reference

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The Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Ansamitocin by Actinosynnema pretiosum

21 January 2018

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The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

21 January 2018

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Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum.

21 January 2018

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Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia

21 January 2018

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Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997

21 January 2018

1 reference

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Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

21 January 2018

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A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997.

21 January 2018

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Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety

21 January 2018

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Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.

21 January 2018

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New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis

21 January 2018

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Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

21 January 2018

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Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin

21 January 2018

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A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A.

21 January 2018

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Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

21 January 2018

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Ansaetherone, a new radical scavenger from Streptomyces sp.

21 January 2018

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Synthesis of the tetracyclic core of tetrapetalone A enabled by a pyrrole reductive alkylation

21 January 2018

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Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

21 January 2018

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Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.

21 January 2018

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Synthetic and biosynthetic studies on FR900482 and mitomycin C: an efficient and stereoselective hydroxymethylation of an advanced benzazocane intermediate

21 January 2018

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Cebulactams A1 and A2, new macrolactams isolated from Saccharopolyspora cebuensis, the first obligate marine strain of the genus Saccharopolyspora

21 January 2018

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Total Synthesis of (−)-Saliniketals A and B†

21 January 2018

1 reference

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Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427.

21 January 2018

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Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

21 January 2018

1 reference

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