(Q45079863)

9 December 2017

title

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites (English)

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9 December 2017

Navneet Kaur

5

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Young-Soo Hong

object named as

Young-Soo Hong

13

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author name string

Kyeong Lee

1

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9 December 2017

Jung S Ryu

2

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9 December 2017

Yinglan Jin

3

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9 December 2017

Woncheol Kim

4

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9 December 2017

Sang J Chung

6

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9 December 2017

Yong-Jin Jeon

7

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9 December 2017

Joon-Tae Park

8

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9 December 2017

Ji S Bang

9

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9 December 2017

Hong S Lee

10

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9 December 2017

Tae Y Kim

11

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9 December 2017

Jung J Lee

12

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9 December 2017

publication date

30 November 2007

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Organic and Biomolecular Chemistry

9 December 2017

published in

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9 December 2017

volume

6

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9 December 2017

issue

2

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9 December 2017

page(s)

340-348

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Therapeutic and diagnostic implications of Hsp90 activation

9 December 2017

cites work

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Molecular chaperones and the stress of oncogenesis

21 January 2018

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Cancer: the rules of attraction

21 January 2018

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HSP90 and the chaperoning of cancer

21 January 2018

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Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation

21 January 2018

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21 January 2018

Heat shock protein 90.

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

21 January 2018

1 reference

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

21 January 2018

1 reference

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

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Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance

21 January 2018

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Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

21 January 2018

1 reference

In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative

21 January 2018

1 reference

Heat shock proteins and acute leukemias

21 January 2018

1 reference

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

21 January 2018

1 reference

Structure-based design of 7-carbamate analogs of geldanamycin

21 January 2018

1 reference

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives

21 January 2018

1 reference

Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems

21 January 2018

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Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

21 January 2018

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Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring.

21 January 2018

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Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

21 January 2018

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Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety

21 January 2018

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p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

21 January 2018

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

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Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B713407J

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9 December 2017

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