(Q34261616)

English

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Andrew D. Mesecar

8

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12 March 2020

Katrina Sleeman

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Katrina Sleeman

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12 March 2020

9

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Susan C Baker

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12 March 2020

Amornrat O'Brien

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Amornrat O'Brien

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12 March 2020

1

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Xufang Deng

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12 March 2020

Bridget S Banach

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Bridget S Banach

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12 March 2020

2

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Sarah E StJohn

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12 March 2020

author name string

Heather L Osswald

3

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12 March 2020

Arun K Ghosh

7

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12 March 2020

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6 August 2014

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12 March 2020

Journal of Virology

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12 March 2020

88

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12 March 2020

20

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Europe PubMed Central

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12 March 2020

11886-11898

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

1 reference

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6 July 2018

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

1 reference

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6 July 2018

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

1 reference

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6 July 2018

ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV.

1 reference

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6 July 2018

Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection

1 reference

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6 July 2018

Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection

1 reference

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6 July 2018

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

1 reference

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6 July 2018

Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility.

1 reference

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6 July 2018

Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Recent trends in HIV-1 drug resistance

1 reference

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6 July 2018

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus [...]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Foldon unfolding mediates the interconversion between M(pro)-C monomer and 3D domain-swapped dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Activation and maturation of SARS-CoV main protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Hepatitis C virus resistance to protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Rapid emergence of protease inhibitor resistance in hepatitis C virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1

1 reference

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6 July 2018

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

1 reference

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6 July 2018

Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

1 reference

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6 July 2018

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4178758

6 July 2018

Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus

1 reference

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Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

1 reference

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6 July 2018

A previously undescribed coronavirus associated with respiratory disease in humans

1 reference

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6 July 2018

Identification of a new human coronavirus

1 reference

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6 July 2018

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

1 reference

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Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

1 reference

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6 July 2018

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

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6 July 2018

Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.

1 reference

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6 July 2018

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

1 reference

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6 July 2018

RNA replication of mouse hepatitis virus takes place at double-membrane vesicles

1 reference

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Virus-encoded proteinases and proteolytic processing in the Nidovirales.

1 reference

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6 July 2018

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1 reference

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6 July 2018

Morphogenesis of Avian Infectious Bronchitis Virus and a Related Human Virus (Strain 229E)

1 reference

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6 July 2018

Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture.

1 reference

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1 reference

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1 reference

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1 reference

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Severe acute respiratory syndrome

1 reference

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1 reference

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1 reference

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28 October 2018

A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/25100843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities -

1 reference

https://pubmed.ncbi.nlm.nih.gov/25100843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01528-14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100843%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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