(Q34263614)

English

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice (English)

1 reference

Europe PubMed Central

1 August 2017

author name string

Kristin Kemmerich

1

1 reference

Europe PubMed Central

1 August 2017

Felix A Dingler

2

1 reference

Europe PubMed Central

1 August 2017

Cristina Rada

3

1 reference

Europe PubMed Central

1 August 2017

Michael S Neuberger

4

1 reference

Europe PubMed Central

1 August 2017

language of work or name

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publication date

24 March 2012

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Europe PubMed Central

1 August 2017

Nucleic Acids Research

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Europe PubMed Central

1 August 2017

40

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Europe PubMed Central

1 August 2017

13

1 reference

Europe PubMed Central

1 August 2017

6016-6025

1 reference

Europe PubMed Central

1 August 2017

copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

4 October 2016

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3401444/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

1 reference

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1 reference

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1 reference

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1 reference

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Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

1 reference

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1 reference

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

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1 reference

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Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

1 reference

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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

1 reference

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Reprogramming towards pluripotency requires AID-dependent DNA demethylation

1 reference

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Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil

1 reference

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

1 reference

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1 reference

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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

1 reference

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1 reference

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Dependence of antibody gene diversification on uracil excision.

1 reference

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Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

1 reference

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1 reference

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SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

1 reference

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C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases

1 reference

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Retroviral restriction by APOBEC proteins

1 reference

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6 July 2018

Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase

1 reference

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Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

1 reference

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Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1

1 reference

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Mammalian 5-Formyluracil−DNA Glycosylase. 2. Role of SMUG1 Uracil−DNA Glycosylase in Repair of 5-Formyluracil and Other Oxidized and Deaminated Base Lesions

1 reference

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The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs

1 reference

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Uracil in DNA--occurrence, consequences and repair

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

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6 July 2018

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

1 reference

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Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

1 reference

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Characterization of the substrate specificity of a human 5-hydroxymethyluracil glycosylase activity

1 reference

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

1 reference

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Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

1 reference

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An unexpectedly high excision capacity for mispaired 5-hydroxymethyluracil in human cell extracts

1 reference

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1 reference

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1 reference

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1 reference

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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1 reference

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1 reference

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Instability and decay of the primary structure of DNA

1 reference

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Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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MSH2 deficient mice are viable and susceptible to lymphoid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

6 July 2018

Hydroxymethyluracil DNA glycosylase in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

6 July 2018

Phylogenetic evidence of a role for 5-hydroxymethyluracil-DNA glycosylase in the maintenance of 5-methylcytosine in DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

6 July 2018

A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

28 October 2018

hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

28 October 2018

Substrate recognition by a family of uracil-DNA glycosylases: UNG, MUG, and TDG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401444

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5-Hydroxymethyl-2′-deoxyuridine, a normal DNA constituent in certain Bacillus subtilis phages is cytostatic for mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Hydroxymethyluracil-DNA glycosylase activity may be a differentiated mammalian function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22447450

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKS259

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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