(Q35447633)

English

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation (English)

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Europe PubMed Central

PubMed publication ID

8 August 2017

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Torkild Visnes

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Cathrine B Vågbø

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Cathrine Broberg Vågbø

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object named as

Geir Slupphaug

6

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Hans Einar Krokan

8

object named as

Hans E Krokan

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Europe PubMed Central

PubMed publication ID

8 August 2017

7

object named as

Bodil Kavli

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

5

object named as

Berit Doseth

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Europe PubMed Central

PubMed publication ID

8 August 2017

Henrik Sahlin Pettersen

1

object named as

Henrik Sahlin Pettersen

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Europe PubMed Central

PubMed publication ID

8 August 2017

author name string

Eva K Svaasand

4

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Europe PubMed Central

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8 August 2017

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publication date

10 July 2011

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Europe PubMed Central

PubMed publication ID

8 August 2017

Nucleic Acids Research

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Europe PubMed Central

PubMed publication ID

8 August 2017

39

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Europe PubMed Central

PubMed publication ID

8 August 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

8430-8444

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

4 October 2016

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3201877/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

1 reference

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Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.

1 reference

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Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer

1 reference

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PARP inhibition: PARP1 and beyond

1 reference

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Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites

1 reference

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27 July 2018

Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil

1 reference

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27 July 2018

Participation of DNA repair in the response to 5-fluorouracil

1 reference

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The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine

1 reference

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Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

1 reference

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27 July 2018

5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems

1 reference

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Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.

1 reference

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27 July 2018

Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

1 reference

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27 July 2018

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

1 reference

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27 July 2018

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

1 reference

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Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency

1 reference

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The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

1 reference

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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

1 reference

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DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

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1 reference

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Involvement of base excision repair in response to therapy targeted at thymidylate synthase

1 reference

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Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil.

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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

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Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.

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MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

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Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

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5-Fluorouracil: mechanisms of action and clinical strategies

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Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1

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Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.

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Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer

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Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

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Biochemical analysis of toxic effects of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells

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Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells

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A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

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Cytotoxic mechanisms of 5-fluoropyrimidines. Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids

1 reference

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Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745813

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Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

1 reference

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based on heuristic

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Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745813

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Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study

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Identifiers

10.1093/NAR/GKR563

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

ResearchGate publication ID

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