(Q34266641)

English

Generation of Predictive Pharmacophore Models for CCR5 Antagonists: Study with Piperidine- and Piperazine-Based Compounds as a New Class of HIV-1 Entry Inhibitors

scientific article published on October 9, 2003

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

1 August 2017

Generation of predictive pharmacophore models for CCR5 antagonists: study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors (English)

1 reference

Europe PubMed Central

1 August 2017

Generation of Predictive Pharmacophore Models for CCR5 Antagonists: Study with Piperidine- and Piperazine-Based Compounds as a New Class of HIV-1 Entry Inhibitors (English)

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

CCR5 receptor antagonist

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14521412

16 March 2024

molecular medicine

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

author name string

Asim Kumar Debnath

1

1 reference

Europe PubMed Central

1 August 2017

language of work or name

0 references

publication date

1 October 2003

1 reference

Europe PubMed Central

1 August 2017

9 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14521412

16 March 2024

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/jm030265z

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

1 August 2017

46

1 reference

Europe PubMed Central

1 August 2017

21

1 reference

Europe PubMed Central

1 August 2017

4501-4515

1 reference

Europe PubMed Central

1 August 2017

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.270.5243.1811

Severe anemia as a newly recognized side-effect caused by lamivudine

2

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Rash as side-effect of nelfinavir in children

3

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Direct analysis of mitochondrial toxicity of antiretroviral drugs

6

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Resistance profiles of cyclic and linear inhibitors of HIV-1 protease

7

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

HIV resistance to antiretroviral drugs: mechanisms, genotypic and phenotypic resistance testing in clinical practice

8

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

TreatmentUpdate

10

12

3

author name string

Fusion 0

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Entry Inhibitors SCH-C, RANTES, and T-20 Block HIV Type 1 Replication in Multiple Cell Types

15

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

16

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

HIV-1 entry and how to block it.

17

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Co-receptors for HIV-1 entry

18

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

HIV-1 entry inhibitors in the side pocket

19

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

24

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

26

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

27

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity

28

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

29

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

30

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

31

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

32

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides

33

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Drug-like properties and the causes of poor solubility and poor permeability

34

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

35

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

37

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

A pharmacophore model for dopamine D4 receptor antagonists

39

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Pharmacophore development for antagonists at α1 adrenergic receptor subtypes

40

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Developing a dynamic pharmacophore model for HIV-1 integrase.

41

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Automated pharmacophore identification for large chemical data sets

42

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase

43

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Drug Metabolism and Disposition

44

29

944

author name string

Ekins S.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

In vitro and pharmacophore insights into CYP3A enzymes

45

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors

46

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

47

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

History and evolution of the pharmacophore concept in computer-aided drug design

48

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Identification of a stable chymase inhibitor using a pharmacophore-Based database search

51

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification

52

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Pharmacophore modeling and three-dimensional database searching for drug design using catalyst

53

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Application of pharmacophore models for the design and synthesis of new anticonvulsant drugs

54

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Lead generation using pharmacophore mapping and three-dimensional database searching: application to muscarinic M(3) receptor antagonists

55

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

A comparison of the pharmacophore identification programs: Catalyst, DISCO and GASP.

56

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

The price of innovation: new estimates of drug development costs

57

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides

58

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

59

13

712

author name string

Palani A.

publication date

2003

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

61

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Journal of Chemical Information and Computer Sciences

63

35

294

author name string

Smellie A.

publication date

1995

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Mining the Chemical Abstracts database with pharmacophore-based queries

67

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching

69

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

71

11

2745

author name string

Hale J. J.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

72

11

1440

author name string

Hale J. J.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

73

12

3000

author name string

Hale J. J.

publication date

2002

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

74

12

3004

author name string

Lynch C. L.

publication date

2002

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

75

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

76

12

679

author name string

Lynch C. L.

publication date

2002

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

78

11

264

author name string

Dorn C. P.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

79

11

2479

author name string

Finke P. E.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

80

11

2473

author name string

Finke P. E.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

81

11

270

author name string

Finke P. E.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

82

11

3106

author name string

Kim D.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Bioorganic & Medicinal Chemistry Letters

83

11

3102

author name string

Kim D.

publication date

2001

1 reference

10.1021/JM030265Z

https://api.crossref.org/works/10.1021/JM030265Z

16 March 2024

Identifiers

10.1021/JM030265Z

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34266641&oldid=2103477044"