(Q34268133)

1 August 2017

title

Germinal center selection and the development of memory B and plasma cells (English)

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1 August 2017

1

Mark J Shlomchik

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1 August 2017

Florian Weisel

2

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1 August 2017

publication date

1 May 2012

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1 August 2017

published in

Immunological Reviews

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1 August 2017

volume

247

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1 August 2017

issue

1

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1 August 2017

page(s)

52-63

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

1 August 2017

1 reference

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Extrafollicular antibody responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

In situ studies of the antigen-driven somatic hypermutation of immunoglobulin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal centers develop oligoclonally

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Memory B-cell persistence is independent of persisting immunizing antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Persistence of memory B cells in mice deprived of T cell help.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Naive and memory B cells respond differentially to T-dependent signaling but display an equal potential for differentiation toward the centroblast-restricted CD77/globotriaosylceramide phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Activation of Virus-specific Memory B Cells in the Absence of T Cell Help

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Hapten-specific stimulation of secondary B cells independent of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Unique requirements for reactivation of virus-specific memory B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

The role of CD40 ligand in costimulation and T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Antigen-specific memory B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Multiple layers of B cell memory with different effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Different B cell populations mediate early and late memory during an endogenous immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

T cell-independent B cell memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

T-independent type II immune responses generate memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B1b lymphocytes confer T cell-independent long-lasting immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Intrinsic properties of human and murine memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal centers without T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Two waves of memory B-cell generation in the primary immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal-center-derived B-cell memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cell activation state-governed formation of germinal centers following viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

New markers for murine memory B cells that define mutated and unmutated subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Phenotypic and functional heterogeneity of human memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Discriminating gene expression profiles of memory B cell subpopulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Gene expression dynamics during germinal center transit in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

CD27 expression by a distinct subpopulation of human B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B-cell kinetics in humans: rapid turnover of peripheral blood memory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Humoral immunity due to long-lived plasma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal-center organization and cellular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Deriving a germinal center lymphocyte migration model from two-photon data

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

In vivo imaging studies shed light on germinal-centre development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Toward quantitative simulation of germinal center dynamics: biological and modeling insights from experimental validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

An analysis of B cell selection mechanisms in germinal centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal centres seen through the mathematical eye: B-cell models on the catwalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Modeling and optimization of populations subject to time-dependent mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Antigen affinity discrimination is an intrinsic function of the B cell receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cell ligand discrimination through a spreading and contraction response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

It's all about change: the antigen-driven initiation of B-cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

The tipping points in the initiation of B cell signalling: how small changes make big differences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Early events in B cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cells acquire antigen from target cells after synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Conduits mediate transport of low-molecular-weight antigen to lymph node follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Foxp3+ follicular regulatory T cells control the germinal center response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cells extract and present immobilized antigen: implications for affinity discrimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B cell antigen receptor signaling and internalization are mutually exclusive events

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

High affinity germinal center B cells are actively selected into the plasma cell compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Transcriptional analysis of the B cell germinal center reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Cytokine control of memory B cell homing machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

Mechanism of antigen-driven selection in germinal centres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01124.X

10.1111/J.1600-065X.2012.01124.X

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference