(Q34274771)

1 August 2017

title

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. (English)

1 reference

1 August 2017

Haijun Chen

1

1 reference

1 August 2017

Tamara Tsalkova

2

1 reference

1 August 2017

Fang C Mei

3

1 reference

1 August 2017

Yaohua Hu

4

1 reference

1 August 2017

Xiaodong Cheng

5

1 reference

1 August 2017

Jia Zhou

6

1 reference

1 August 2017

language of work or name

English

0 references

publication date

26 April 2012

1 reference

Bioorganic & Medicinal Chemistry Letters

1 August 2017

published in

1 reference

1 August 2017

volume

22

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1 August 2017

issue

12

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1 August 2017

page(s)

4038-4043

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A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists

1 August 2017

cites work

1 reference

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Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model

6 July 2018

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Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

6 July 2018

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The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity

6 July 2018

1 reference

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Mapping allostery through the covariance analysis of NMR chemical shifts

6 July 2018

1 reference

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Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications

6 July 2018

1 reference

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Epac: defining a new mechanism for cAMP action

6 July 2018

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The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

6 July 2018

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The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs

6 July 2018

1 reference

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Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities

6 July 2018

1 reference

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

6 July 2018

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Dynamically driven ligand selectivity in cyclic nucleotide binding domains

6 July 2018

1 reference

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Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro

6 July 2018

1 reference

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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

6 July 2018

1 reference

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8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

6 July 2018

1 reference

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Epac and PKA: a tale of two intracellular cAMP receptors

6 July 2018

1 reference

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Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

6 July 2018

1 reference

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cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

6 July 2018

1 reference

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Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction

6 July 2018

1 reference

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Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

A family of cAMP-binding proteins that directly activate Rap1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Modulation of inflammation and immunity by cyclic AMP.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Cyclic nucleotide analogs as probes of signaling pathways.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Cyclic nucleotide research -- still expanding after half a century

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362663

Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22607683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2012.04.082

1 reference

1 August 2017

1 reference

1 August 2017

1 reference