(Q34282839)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

review article

1 reference

title

Ace revisited: a new target for structure-based drug design (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1

1 reference

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21 December 2019

author name string

Edward D Sturrock

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

James F Riordan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Mario R W Ehlers

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

publication date

1 November 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

21 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

volume

2

1 reference

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21 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

page(s)

891-902

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd1227

21 December 2019

exact match

0 references

cites work

High-throughput crystallography for lead discovery in drug design.

1 reference

The genesis of high-throughput structure-based drug discovery using protein crystallography

21 January 2018

1 reference

The angiotensin-converting enzyme gene family: genomics and pharmacology

21 January 2018

1 reference

Drugs targeting the renin-angiotensin-aldosterone system

21 January 2018

1 reference

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

21 January 2018

1 reference

The development of COX2 inhibitors

21 January 2018

1 reference

21 January 2018

1 reference

Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States

21 January 2018

1 reference

The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme

21 January 2018

1 reference

RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites

21 January 2018

1 reference

Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors

21 January 2018

1 reference

Angiotensin-converting enzyme and male fertility

21 January 2018

1 reference

Human performance: a role for the ACE genotype?

21 January 2018

1 reference

Proteolytic release of membrane-bound angiotensin-converting enzyme: role of the juxtamembrane stalk sequence

21 January 2018

1 reference

Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

21 January 2018

1 reference

The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue

21 January 2018

1 reference

Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme.

21 January 2018

1 reference

Just the beginning: novel functions for angiotensin-converting enzymes

21 January 2018

1 reference

Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

21 January 2018

1 reference

Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity

21 January 2018

1 reference

Structure of neurolysin reveals a deep channel that limits substrate access

21 January 2018

1 reference

Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus

21 January 2018

1 reference

Enzymes of the Renin-Angiotensin System and their Inhibitors

21 January 2018

1 reference

Design of angiotensin converting enzyme inhibitors.

21 January 2018

1 reference

2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery

21 January 2018

1 reference

The Discovery of Captopril

21 January 2018

1 reference

Silicon-based metalloprotease inhibitors: synthesis and evaluation of silanol and silanediol peptide analogues as inhibitors of angiotensin-converting enzyme

21 January 2018

1 reference

Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan

21 January 2018

1 reference

Enhancement of bradykinin and resensitization of its B2 receptor.

21 January 2018

1 reference

Angiotensin blockade for hypertension: a promise fulfilled

21 January 2018

1 reference

Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE II.

21 January 2018

1 reference

Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators

21 January 2018

1 reference

Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril

21 January 2018

1 reference

21 January 2018

Vasopeptidase inhibitors

1 reference

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

Omapatrilat--the story of Overture and Octave

21 January 2018

1 reference

Vasopeptidase inhibition: a double-edged sword?

21 January 2018

1 reference

A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure

21 January 2018

1 reference

N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities

21 January 2018

1 reference

Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin

21 January 2018

1 reference

Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade

21 January 2018

1 reference

Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline

21 January 2018

1 reference

Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.

21 January 2018

1 reference

Angiotensin-converting-enzyme inhibition therapy in altitude polycythaemia: a prospective randomised trial

21 January 2018

1 reference

Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides

21 January 2018

1 reference

Integration of virtual and high-throughput screening

21 January 2018

1 reference

Structure-based screening and design in drug discovery

21 January 2018

1 reference

Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors

21 January 2018

1 reference

Comparative pharmacology of H1 antihistamines: clinical relevance

21 January 2018

1 reference

STUDIES ON EXPERIMENTAL HYPERTENSION : I. THE PRODUCTION OF PERSISTENT ELEVATION OF SYSTOLIC BLOOD PRESSURE BY MEANS OF RENAL ISCHEMIA.

31 March 2020

1 reference

A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR

31 March 2020

1 reference

The purification of hypertensin I.

31 March 2020

1 reference

The preparation and function of the hypertensin-converting enzyme

31 March 2020

1 reference

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

31 March 2020

1 reference

Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme

31 March 2020

1 reference

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

31 March 2020

1 reference

Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications

31 March 2020

1 reference

Insect angiotensin-converting enzyme. A processing enzyme with broad substrate specificity and a role in reproduction

31 March 2020

1 reference

Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril

31 March 2020

1 reference

Effects of the N-terminal sequence of ACE on the properties of its C-domain

31 March 2020

1 reference

Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes

31 March 2020

1 reference

Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung

31 March 2020

1 reference

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids

31 March 2020

1 reference

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

31 March 2020

1 reference

Zinc coordination, function, and structure of zinc enzymes and other proteins

31 March 2020

1 reference

Conversion of angiotensin I to angiotensin II.

31 March 2020

1 reference

Fate of angiotensin I in the circulation

31 March 2020

1 reference

Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog Lung

31 March 2020

1 reference

Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme

31 March 2020

1 reference

Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis

31 March 2020

1 reference

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

31 March 2020

1 reference

A new class of angiotensin-converting enzyme inhibitors

31 March 2020

1 reference

Metal-coordinating substrate analogs as inhibitors of metalloenzymes

31 March 2020

1 reference

Dipeptide-hydroxamates are good inhibitors of the angiotensin I-converting enzyme

31 March 2020

1 reference

Synthesis and biological activity of a ketomethylene analog of a tripeptide inhibitor of angiotensin converting enzyme

31 March 2020

1 reference

Mechanisms of cardiovascular risk reduction with ramipril: insights from HOPE and HOPE substudies

31 March 2020

1 reference

The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis

31 March 2020

1 reference

Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.

31 March 2020

1 reference

Potentiation of the actions of bradykinin by angiotensin I-converting enzyme inhibitors. The role of expressed human bradykinin B2 receptors and angiotensin I-converting enzyme in CHO cells

31 March 2020

1 reference

Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells

31 March 2020

1 reference

Can angiotensin receptor antagonists be used safely in patients with previous ACE inhibitor-induced angioedema?

31 March 2020

1 reference

Vasopeptidase inhibition and angio-oedema

31 March 2020

1 reference

MADIT II, the Multi-center Autonomic Defibrillator Implantation Trial II stopped early for mortality reduction, has ICD therapy earned its evidence-based credentials?

31 March 2020

1 reference

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice

31 March 2020

1 reference

N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE

31 March 2020

1 reference

The C‐type natriuretic peptide precursor of snake brain contains highly specific inhibitors of the angiotensin‐converting enzyme

31 March 2020

1 reference

Structural constraints of inhibitors for binding at two active sites on somatic angiotensin converting enzyme

31 March 2020

1 reference

The design and properties of N-carboxyalkyldipeptide inhibitors of angiotensin-converting enzyme

31 March 2020

1 reference

12 December 2020

The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

1 reference

12 December 2020

Pulmonary angiotensin-converting enzyme. Structural and catalytic properties

1 reference

12 December 2020

Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene.

1 reference

12 December 2020

Angiotensin-converting enzyme inhibitors

1 reference

12 December 2020

RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis

1 reference

12 December 2020

Using ACE inhibitors appropriately.

1 reference

12 December 2020

Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides

1 reference

12 December 2020

Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence

1 reference

12 December 2020

Endurance and the ACE I/D polymorphism.

1 reference

12 December 2020

Inhibition of rabbit lung angiotensin-converting enzyme by N alpha-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N alpha-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline.

1 reference

12 December 2020

The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD1227

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14668810%20AND%20SRC:MED&resulttype=core&format=json

release_ry6kgsd4hvcrlfrhku6k6z6nka

21 December 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ry6kgsd4hvcrlfrhku6k6z6nka

24 November 2022

mapped directly with Wikidata item

1 reference