(Q34157437)

31 July 2017

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title

The genesis of high-throughput structure-based drug discovery using protein crystallography (English)

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31 July 2017

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Peter Kuhn

1

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31 July 2017

Keith Wilson

series ordinal

2

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31 July 2017

Marianne G Patch

series ordinal

3

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31 July 2017

Raymond C Stevens

series ordinal

4

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31 July 2017

1 October 2002

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Current Opinion in Chemical Biology

31 July 2017

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31 July 2017

6

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31 July 2017

5

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31 July 2017

704-710

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Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Rational design of potent sialidase-based inhibitors of influenza virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Accelerating code to function: sizing up the protein production line

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

High-throughput proteomics: protein expression and purification in the postgenomic world.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Design of high-throughput methods of protein production for structural biology

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Rapid protein-folding assay using green fluorescent protein

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Phase Determination by Multiple-Wavelength X-Ray Diffraction: Crystal Structure of a Basic "Blue" Copper Protein from Cucumbers

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Cool data: quantity AND quality.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Automation of X-ray crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Automated crystal mounting and data collection for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Recent developments in software for the automation of crystallographic macromolecular structure determination

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Automated protein model building combined with iterative structure refinement

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

High-throughput protein crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

High-throughput x-ray crystallography for structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

An approach to rapid protein crystallization using nanodroplets

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Development of a technology for automation and miniaturization of protein crystallization.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Recent developments in structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

High-throughput docking for lead generation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

High-throughput crystallography for lead discovery in drug design.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

The use of 3D structural data in the design of specific factor Xa inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Optimization of a screening lead for factor VIIa/TF.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Identification of novel inhibitors of urokinase via NMR-based screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Modeling of the binding mode of a non-covalent inhibitor of the 20S proteasome. Application to structure-based analogue design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of potent CDK1 inhibitors derived from olomoucine

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Rational design of potent and selective EGFR tyrosine kinase inhibitors as anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of compounds inhibiting Grb2-SH2 mediated protein-protein interactions in signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of a new class of anti-inflammatory drugs: secretory phospholipase A(2) inhibitors, SPI.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

STAT proteins: novel molecular targets for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1)

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

A structure-based design approach to the development of novel, reversible AChE inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Structure-based design of cyclooxygenase-2 selectivity into ketoprofen

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Neuronal nicotinic receptor agonists: a multi-approach development of the pharmacophore

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

A 3D QSAR study of monoamino oxidase-B inhibitors using the chemical function based pharmacophore generation approach.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

A feature based pharmacophore for Candida albicans MyristoylCoA: protein N-myristoyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

Combinatorial computational method gives new picomolar ligands for a known enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2802%2900361-7

7 January 2021

10.1016/S1367-5931(02)00361-7

Identifiers

DOI

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31 July 2017

1 reference