(Q34283319)

1 August 2017

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap. (English)

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1 August 2017

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Judith Pratt

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1 August 2017

Catherine Winchester

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1 August 2017

Neil Dawson

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1 August 2017

Brian Morris

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1 August 2017

22 June 2012

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

11

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7

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1 August 2017

560-579

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https://scigraph.springernature.com/pub.10.1038/nrd3649

1 August 2017

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cites work

The environment and schizophrenia

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31 March 2020

Rethinking schizophrenia

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Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

31 March 2020

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Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects

31 March 2020

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Elevated striatal dopamine function linked to prodromal signs of schizophrenia

31 March 2020

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Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

31 March 2020

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The NIMH-CATIE Schizophrenia Study: what did we learn?

31 March 2020

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Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles

31 March 2020

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What's atypical about atypical antipsychotic drugs?

31 March 2020

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Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS.

31 March 2020

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Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

31 March 2020

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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

31 March 2020

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Recent advances in the phencyclidine model of schizophrenia

31 March 2020

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Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology

31 March 2020

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Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex

31 March 2020

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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

31 March 2020

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Glutamate receptors and transporters in the hippocampus in schizophrenia.

31 March 2020

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NMDA receptors and schizophrenia.

31 March 2020

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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

31 March 2020

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Genetic data supporting the NMDA glutamate receptor hypothesis for schizophrenia

31 March 2020

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Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?

31 March 2020

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Predicting drug efficacy for cognitive deficits in schizophrenia

31 March 2020

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Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis.

31 March 2020

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Effects of dopamine agonists and antagonists on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test

31 March 2020

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Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

31 March 2020

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Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

31 March 2020

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Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.

31 March 2020

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Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology

31 March 2020

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Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

31 March 2020

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Initial phase 2 trial of a nicotinic agonist in schizophrenia

31 March 2020

1 reference

A review of the effects of modafinil on cognition in schizophrenia

31 March 2020

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Effects of modafinil on cognitive functions in first episode psychosis.

31 March 2020

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Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study

31 March 2020

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PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats

31 March 2020

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5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats

31 March 2020

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PCP: from pharmacology to modelling schizophrenia

31 March 2020

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NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia

31 March 2020

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Cortical inhibitory neurons and schizophrenia

31 March 2020

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GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder

31 March 2020

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Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment

31 March 2020

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GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders

31 March 2020

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Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia

31 March 2020

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The environment and susceptibility to schizophrenia

31 March 2020

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The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia

31 March 2020

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Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood.

31 March 2020

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Social behaviour in rats lesioned with ibotenic acid in the hippocampus: quantitative and qualitative analysis

31 March 2020

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P.3.d.013 Impact of chronic antipsychotic treatments on hypersensitivity to MK-801 in a neurodevelopmental model of schizophrenia

31 March 2020

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Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia

31 March 2020

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Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders.

31 March 2020

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Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia.

31 March 2020

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What is complex about complex disorders?

31 March 2020

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

31 March 2020

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Animal models of gene-environment interactions in schizophrenia

31 March 2020

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Genetic and cognitive windows into circuit mechanisms of psychiatric disease.

31 March 2020

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Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

31 March 2020

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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges

31 March 2020

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Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects

31 March 2020

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Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.

31 March 2020

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Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

31 March 2020

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NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.

31 March 2020

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Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review

31 March 2020

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Behavioral phenotypes of Disc1 missense mutations in mice.

31 March 2020

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Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

31 March 2020

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Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice

31 March 2020

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Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.

31 March 2020

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Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

31 March 2020

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Dopamine transporter mutant mice in experimental neuropharmacology

31 March 2020

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Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice

31 March 2020

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Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons.

31 March 2020

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Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia

31 March 2020

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Convergent approaches for defining functional imaging endophenotypes in schizophrenia

31 March 2020

1 reference

Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder

31 March 2020

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Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.

31 March 2020

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Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study

31 March 2020

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Differential functional connectivity of prefrontal and medial temporal cortices during episodic memory retrieval

31 March 2020

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Evidence for abnormal cortical functional connectivity during working memory in schizophrenia

31 March 2020

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Structural modeling of functional neural pathways mapped with 2-deoxyglucose: effects of acoustic startle habituation on the auditory system.

31 March 2020

1 reference

Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity

31 March 2020

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Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs

31 March 2020

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Modafinil modulates anterior cingulate function in chronic schizophrenia

31 March 2020

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Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

31 March 2020

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Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

31 March 2020

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Complex brain networks: graph theoretical analysis of structural and functional systems

31 March 2020

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Hierarchical organization of human cortical networks in health and schizophrenia

31 March 2020

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Small-world networks and disturbed functional connectivity in schizophrenia.

31 March 2020

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Disrupted small-world networks in schizophrenia.

31 March 2020

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Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior.

31 March 2020

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Insights into cortical oscillations arising from optogenetic studies

31 March 2020

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Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons

31 March 2020

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Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia.

31 March 2020

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Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models

31 March 2020

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Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia

31 March 2020

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Neuroimaging and molecular genetics of schizophrenia: pathophysiological advances and therapeutic potential.

31 March 2020

1 reference

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

31 March 2020

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Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

31 March 2020

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A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

31 March 2020

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Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

31 March 2020

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The effects of a neuregulin 1 variant on white matter density and integrity

31 March 2020

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Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A.

31 March 2020

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Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

31 March 2020

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A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype

31 March 2020

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No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression

31 March 2020

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Negative symptoms in schizophrenia: avolition and Occam's razor

31 March 2020

1 reference

Dopamine D2 receptors as treatment targets in schizophrenia

31 March 2020

1 reference

Antipsychotic occupancy of dopamine receptors in schizophrenia

31 March 2020

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The role of serotonin receptors in the action of atypical antipsychotic drugs

31 March 2020

1 reference

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

31 March 2020

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Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia

31 March 2020

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Forebrain substrates of reward and motivation

31 March 2020

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CNTRICS final task selection: control of attention

31 March 2020

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The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

31 March 2020

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Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: the West London Study.

31 March 2020

1 reference

Medial frontal cortex mediates perceptual attentional set shifting in the rat.

31 March 2020

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Cognition in mouse models of schizophrenia susceptibility genes

31 March 2020

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Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodents

31 March 2020

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Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

31 March 2020

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Understanding the role of DISC1 in psychiatric disease and during normal development

31 March 2020

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Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice

31 March 2020

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A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

31 March 2020

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Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

31 March 2020

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Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits

31 March 2020

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Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

31 March 2020

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Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.

31 March 2020

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Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice

31 March 2020

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Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

31 March 2020

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Neuregulin 1 and susceptibility to schizophrenia

31 March 2020

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Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components

31 March 2020

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Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1.

31 March 2020

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Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse

31 March 2020

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Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system

31 March 2020

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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.

31 March 2020

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Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice

31 March 2020

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Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome

31 March 2020

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Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments.

31 March 2020

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Altered striatal function in a mutant mouse lacking D1A dopamine receptors

31 March 2020

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Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

31 March 2020

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Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice

31 March 2020

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Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor

31 March 2020

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Modeling cognitive endophenotypes of schizophrenia in mice

31 March 2020

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Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

31 March 2020

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Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase

31 March 2020

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Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background

31 March 2020

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Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia

31 March 2020

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Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

31 March 2020

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Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function

31 March 2020

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Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit

31 March 2020

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Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice

31 March 2020

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A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice.

31 March 2020

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Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?

31 March 2020

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Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors

31 March 2020

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Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function

31 March 2020

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Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

31 March 2020

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Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)

31 March 2020

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Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.

31 March 2020

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Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.

31 March 2020

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Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning

31 March 2020

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Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background

31 March 2020

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Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.

31 March 2020

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Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia

31 March 2020

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Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways.

31 March 2020

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NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory

31 March 2020

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Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia

31 March 2020

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A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice

31 March 2020

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Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction

31 March 2020

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Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function

31 March 2020

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STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating

31 March 2020

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Disruption of prepulse inhibition in mice lacking mGluR1.

31 March 2020

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Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice

31 March 2020

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Schizophrenia: a disconnection syndrome?

31 March 2020

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12 December 2020

Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia

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12 December 2020

Deficits of neuronal glutamatergic markers in the caudate nucleus in schizophrenia

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12 December 2020

GABAA receptor alpha2/alpha3 subtype-selective modulators as potential nonsedating anxiolytics

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12 December 2020

Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders.

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12 December 2020

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia

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12 December 2020

Comment on "Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI" and "Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area".

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12 December 2020

Neurocognitive deficit in schizophrenia: a quantitative review of the evidence.

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12 December 2020

Pre-clinical pharmacology of atypical antipsychotic drugs: a selective review

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12 December 2020

Identifiers

DOI

10.1038/NRD3649

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Dimensions Publication ID

1 August 2017

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