(Q34283491)

1 August 2017

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title

Delivery of cell cycle genes to block astrocytoma growth (English)

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1 August 2017

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J Fueyo

1

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1 August 2017

C Gomez-Manzano

series ordinal

2

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1 August 2017

T J Liu

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3

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1 August 2017

W K Yung

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4

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1 August 2017

1 February 2001

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Journal of Neuro-Oncology

1 August 2017

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1 August 2017

51

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1 August 2017

3

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1 August 2017

277-287

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https://scigraph.springernature.com/pub.10.1023/a:1010661131403

1 August 2017

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cites work

Current concepts in neuro-oncology: the cell cycle--a review

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12 December 2020

Chemical inhibitors of cyclin-dependent kinases

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12 December 2020

Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay.

1 reference

12 December 2020

A model for p53-induced apoptosis

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12 December 2020

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1 reference

12 December 2020

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1 reference

12 December 2020

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.

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12 December 2020

Suppression of human glioma growth by adenovirus-mediated Rb gene transfer

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12 December 2020

Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line.

1 reference

12 December 2020

The retinoblastoma gene is involved in malignant progression of astrocytomas

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12 December 2020

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

12 December 2020

The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells

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12 December 2020

Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol

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12 December 2020

Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.

1 reference

12 December 2020

Two regions of the adenovirus early region 1A proteins are required for transformation.

1 reference

12 December 2020

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

12 December 2020

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1 reference

12 December 2020

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

12 December 2020

Deletion and transfection analysis of the p15/MTS2 gene in malignant gliomas.

1 reference

12 December 2020

Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy.

1 reference

12 December 2020

Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo

1 reference

12 December 2020

Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors.

1 reference

12 December 2020

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

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12 December 2020

Mutations in the p53 gene occur in diverse human tumour types

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12 December 2020

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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12 December 2020

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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12 December 2020

Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis

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12 December 2020

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

12 December 2020

1 reference

12 December 2020

Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

1 reference

12 December 2020

Distinct roles for E2F proteins in cell growth control and apoptosis

1 reference

12 December 2020

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

12 December 2020

Molecular pathogenesis of malignant gliomas

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells.

1 reference

12 December 2020

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

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12 December 2020

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

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12 December 2020

Loss of PTEN facilitates HIF-1-mediated gene expression

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12 December 2020

Viral transactivating proteins

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12 December 2020

Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells

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12 December 2020

Induction of the growth inhibitor IGF-binding protein 3 by p53

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12 December 2020

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

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12 December 2020

A p53-dependent mouse spindle checkpoint

1 reference

12 December 2020

Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats.

1 reference

12 December 2020

Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.

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12 December 2020

Human wild type p53 inhibits cell proliferation and elicits dramatic morphological changes in human glioma cell lines in vitro

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12 December 2020

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1 reference

12 December 2020

An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy

1 reference

12 December 2020

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

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12 December 2020

Increased levels of p21WAF1/Cip1 in human brain tumors.

1 reference

12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

12 December 2020

Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy

1 reference

12 December 2020

A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

1 reference

12 December 2020

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1 reference

12 December 2020

Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

1 reference

12 December 2020

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53

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12 December 2020

p21 is a universal inhibitor of cyclin kinases

1 reference

12 December 2020

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

12 December 2020

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1 reference

12 December 2020

Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro

1 reference

12 December 2020

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

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12 December 2020

Mutations of the p16 gene in gliomas.

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12 December 2020

Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses

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12 December 2020

Anticancer drug targets: cell cycle and checkpoint control.

1 reference

12 December 2020

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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12 December 2020

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

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12 December 2020

Cellular targets for transformation by the adenovirus E1A proteins

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12 December 2020

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

1 reference

12 December 2020

Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors

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12 December 2020

Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene

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12 December 2020

Distinct roles for cyclin-dependent kinases in cell cycle control

1 reference

12 December 2020

Genetic determinants of p53-induced apoptosis and growth arrest

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12 December 2020

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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12 December 2020

Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1.

1 reference

12 December 2020

Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes

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12 December 2020

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

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12 December 2020

Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.

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12 December 2020

Replacement of the p16/CDKN2 gene suppresses human glioma cell growth

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12 December 2020

ONYX-015: clinical data are encouraging

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12 December 2020

Evidence for a second cell cycle block at G2/M by p53.

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12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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12 December 2020

Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells

1 reference

12 December 2020

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

12 December 2020

Adenovirus E1A targets key regulators of cell proliferation

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12 December 2020

Mutation rate of the CDKN2 gene in malignant gliomas.

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12 December 2020

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

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12 December 2020

Clonal expansion of p53 mutant cells is associated with brain tumour progression

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12 December 2020

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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12 December 2020

Deletion of p16 and p15 genes in brain tumors

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12 December 2020

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

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12 December 2020

Identifiers

DOI

10.1023/A:1010661131403

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Dimensions Publication ID

1 August 2017

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