(Q34288648)

1 August 2017

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title

RAG1 and RAG2 in V(D)J recombination and transposition (English)

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1 August 2017

Fugmann SD

1

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1 August 2017

1 January 2001

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1 August 2017

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1 August 2017

23

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1 August 2017

23-39

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1 August 2017

1

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https://scigraph.springernature.com/pub.10.1385/ir:23:1:23

1 August 2017

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Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

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12 December 2020

DNA end-joining: from yeast to man

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12 December 2020

Tn10 and IS10 transposition and chromosome rearrangements: mechanism and regulation in vivo and in vitro.

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12 December 2020

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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12 December 2020

The V(D)J recombination activating gene, RAG-1.

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12 December 2020

Functional analysis of coordinated cleavage in V(D)J recombination

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12 December 2020

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

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12 December 2020

Specific recognition of cruciform DNA by nuclear protein HMG1.

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12 December 2020

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

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12 December 2020

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

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12 December 2020

Drosophila kelch motif is derived from a common enzyme fold

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12 December 2020

Cell-cycle regulation of mammalian DNA double-strand-break repair

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12 December 2020

In vitro V(D)J recombination: signal joint formation

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12 December 2020

Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

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12 December 2020

Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

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12 December 2020

Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

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12 December 2020

High-resolution structure of the catalytic domain of avian sarcoma virus integrase

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12 December 2020

Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies

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12 December 2020

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

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12 December 2020

Regions of RAG1 protein critical for V(D)J recombination

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12 December 2020

Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration

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12 December 2020

Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast

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12 December 2020

Factors and forces controlling V(D)J recombination

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12 December 2020

Three-dimensional clustering of human RAG2 gene mutations in severe combined immune deficiency.

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12 December 2020

A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

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12 December 2020

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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12 December 2020

Identification of residues in the Mu transposase essential for catalysis

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12 December 2020

Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex

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12 December 2020

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

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12 December 2020

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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12 December 2020

Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin

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12 December 2020

A zinc-binding domain involved in the dimerization of RAG1

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12 December 2020

Stimulation of V(D)J cleavage by high mobility group proteins

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12 December 2020

Definition of a core region of RAG-2 that is functional in V(D)J recombination

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12 December 2020

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

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12 December 2020

kelch encodes a component of intercellular bridges in Drosophila egg chambers

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12 December 2020

Stimulation of V(D)J recombination by histone acetylation

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12 December 2020

Coding joint formation in a cell-free V(D)J recombination system

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12 December 2020

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution

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12 December 2020

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

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12 December 2020

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches

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12 December 2020

Formation and resolution of double-strand break intermediates in V(D)J rearrangement

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12 December 2020

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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12 December 2020

Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin

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12 December 2020

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

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12 December 2020

The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

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12 December 2020

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

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12 December 2020

Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity

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12 December 2020

V(D)J recombination: in vitro coding joint formation

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12 December 2020

Somatic generation of antibody diversity

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12 December 2020

Rejoining of DNA by the RAG1 and RAG2 proteins.

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12 December 2020

Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases

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12 December 2020

Expression and V(D)J recombination activity of mutated RAG-1 proteins

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12 December 2020

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

1 reference

12 December 2020

Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2

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12 December 2020

Disassembly of the Mu transposase tetramer by the ClpX chaperone

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12 December 2020

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

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12 December 2020

All three residues of the Tn 10 transposase DDE catalytic triad function in divalent metal ion binding

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12 December 2020

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12 December 2020

A general two-metal-ion mechanism for catalytic RNA

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12 December 2020

RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

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12 December 2020

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

1 reference

12 December 2020

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

1 reference

12 December 2020

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

1 reference

12 December 2020

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

1 reference

12 December 2020

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

1 reference

12 December 2020

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1 reference

12 December 2020

The kelch repeat superfamily of proteins: propellers of cell function

1 reference

12 December 2020

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2

1 reference

12 December 2020

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

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12 December 2020

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

1 reference

12 December 2020

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

1 reference

12 December 2020

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

1 reference

12 December 2020

A role for histone acetylation in the developmental regulation of VDJ recombination.

1 reference

12 December 2020

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

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12 December 2020

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

1 reference

12 December 2020

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

1 reference

12 December 2020

A minimal system for Tn7 transposition: the transposon-encoded proteins TnsA and TnsB can execute DNA breakage and joining reactions that generate circularized Tn7 species

1 reference

12 December 2020

Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

1 reference

12 December 2020

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

1 reference

12 December 2020

rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent

1 reference

12 December 2020

The PHD finger: implications for chromatin-mediated transcriptional regulation

1 reference

12 December 2020

A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity

1 reference

12 December 2020

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

1 reference

12 December 2020

Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination

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12 December 2020

RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

1 reference

12 December 2020

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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12 December 2020

Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.

1 reference

12 December 2020

Analysis of regions of RAG-2 important for V(D)J recombination

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12 December 2020

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

1 reference

12 December 2020

Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase

1 reference

12 December 2020

New insights into V(D)J recombination and its role in the evolution of the immune system

1 reference

12 December 2020

Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

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12 December 2020

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

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12 December 2020

Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

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12 December 2020

Cell-free V(D)J recombination

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12 December 2020

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

1 reference

12 December 2020

The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis

1 reference

12 December 2020

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

1 reference

12 December 2020

Identifiers

DOI

10.1385/IR:23:1:23

1 reference

PubMed ID

11417858

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11417858