(Q34288930)

English

Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

molecular chaperones

0 references

author name string

Kate L Moreau

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Jonathan A King

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

0 references

publication date

24 May 2012

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

e37256

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

copyright license

Creative Commons Attribution 4.0 International

24 May 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Increased hydrophobicity and decreased backbone flexibility explain the lower solubility of a cataract-linked mutant of γD-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The congenital cataract-linked G61C mutation destabilizes γD-crystallin and promotes non-native aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

A Single Mutation Promotes Amyloidogenicity through a Highly Promiscuous Dimer Interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Aggregation of deamidated human betaB2-crystallin and incomplete rescue by alpha-crystallin chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

beta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Formation of amyloid fibrils in vitro from partially unfolded intermediates of human gammaC-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The G18V CRYGS mutation associated with human cataracts increases gammaS-crystallin sensitivity to thermal and chemical stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Conformational pathology of the serpins: themes, variations, and therapeutic strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Altered Dimer Interface Decreases Stability in an Amyloidogenic Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Formation of amyloid fibrils in vitro by human gammaD-crystallin and its isolated domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

GammaD-crystallin associated protein aggregation and lens fiber cell denucleation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Deamidation alters the structure and decreases the stability of human lens betaA3-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Alpha-crystallin expression affects microtubule assembly and prevents their aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Deamidation in human lens betaB2-crystallin destabilizes the dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Contributions of hydrophobic domain interface interactions to the folding and stability of human gammaD-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Congenital hereditary cataracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Altered aggregation properties of mutant gamma-crystallins cause inherited cataract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Interaction of human recombinant alphaA- and alphaB-crystallins with early and late unfolding intermediates of citrate synthase on its thermal denaturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Crystal cataracts: human genetic cataract caused by protein crystallization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Link between a novel human gammaD-crystallin allele and a unique cataract phenotype explained by protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Molecular basis of a progressive juvenile-onset hereditary cataract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The interaction of the molecular chaperone, alpha-crystallin, with molten globule states of bovine alpha-lactalbumin

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Preferential interaction of alpha crystallin with denatured forms of gamma crystallin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Chaperone activity of alpha-crystallins modulates intermediate filament assembly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

In vitro studies on the assembly properties of the lens proteins CP49, CP115: coassembly with alpha-crystallin but not with vimentin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Sickle cell hemoglobin polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Alpha-crystallin can function as a molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360035

6 July 2018

The P23T cataract mutation causes loss of solubility of folded gammaD-crystallin.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

In vitro unfolding, refolding, and polymerization of human gammaD crystallin, a protein involved in cataract formation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Interaction of alpha-crystallin with spin-labeled peptides.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Lens alpha-crystallin: chaperone-like properties

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Folding and stability of the isolated Greek key domains of the long-lived human lens proteins gammaD-crystallin and gammaS-crystallin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Interdomain side-chain interactions in human gammaD crystallin influencing folding and stability

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037256

21 January 2018

Temperature-dependent chaperone activity and structural properties of human alphaA- and alphaB-crystallins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22655036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22655036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of destabilized betaB2-crystallin mutants to alpha-crystallin: the role of a folding intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22655036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding

1 reference

https://pubmed.ncbi.nlm.nih.gov/22655036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/22655036

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0037256

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

2012PLoSO...737256M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34288930&oldid=1966774401"