(Q34295282)

1 August 2017

title

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors (English)

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1 August 2017

13

Bjoern Peters

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1 August 2017

14

Anjana Rao

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1 August 2017

Hozefa S Bandukwala

1

1 reference

1 August 2017

John Gagnon

2

1 reference

1 August 2017

Susan Togher

3

1 reference

1 August 2017

Jason A Greenbaum

4

1 reference

1 August 2017

Edward D Lamperti

5

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1 August 2017

Nigel J Parr

6

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1 August 2017

Amy M H Molesworth

7

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1 August 2017

Nicholas Smithers

8

1 reference

1 August 2017

Kevin Lee

9

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1 August 2017

Jason Witherington

10

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1 August 2017

David F Tough

11

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1 August 2017

Rab K Prinjha

12

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1 August 2017

language of work or name

English

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publication date

21 August 2012

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

109

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1 August 2017

issue

36

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1 August 2017

page(s)

14532-14537

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Place your BETs: the therapeutic potential of bromodomains

1 August 2017

cites work

1 reference

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

6 July 2018

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Experimental autoimmune encephalomyelitis--achievements and prospective advances

6 July 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

6 July 2018

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Predisposition to cancer caused by genetic and functional defects of mammalian Atad5

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

6 July 2018

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Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development

6 July 2018

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Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis

6 July 2018

1 reference

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Myeloid cells migrate in response to IL-24.

6 July 2018

1 reference

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Discovery and characterization of small molecule inhibitors of the BET family bromodomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Suppression of inflammation by a synthetic histone mimic

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

CXCR3 blockade inhibits T-cell migration into the CNS during EAE and prevents development of adoptively transferred, but not actively induced, disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Selective inhibition of BET bromodomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

6 July 2018

1 reference

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Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Th17 cells in immunity and autoimmunity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

NFATc1 regulates PD-1 expression upon T cell activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

JMJD6 is a histone arginine demethylase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Low molecular weight inhibitors of Myc-Max interaction and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Manipulation of the Th1/Th2 balance in autoimmune disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Sequential expression of genes involved in human T lymphocyte growth and differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437860

The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1212264109

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1212264109

21 January 2018

Identifiers

DOI

10.1073/PNAS.1212264109

1 reference

1 August 2017

0 references

1 reference

1 August 2017

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