(Q34295972)

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Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection (English)

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1 August 2017

Mark A. Brockman

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1 August 2017

Chanson J Brumme

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Chanson J Brumme

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Zabrina L Brumme

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Zabrina L Brumme

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Bruce D. Walker

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Bruce D Walker

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1 August 2017

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Marcus Altfeld

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1 August 2017

David Heckerman

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David Heckerman

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1 August 2017

Hendrik Streeck

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Hendrik Streeck

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1 August 2017

Eric S Rosenberg

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Eric Rosenberg

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1 August 2017

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Todd M Allen

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1 August 2017

Toshiyuki Miura

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Toshiyuki Miura

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1 August 2017

Anthony Kelleher

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Anthony D Kelleher

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1 August 2017

Richard Harrigan

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P Richard Harrigan

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1 August 2017

Pamela C Rosato

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Pamela C Rosato

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1 August 2017

5

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Jennifer Sela

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1 August 2017

Tristan J Markle

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Tristan J Markle

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1 August 2017

author name string

Carl M Kadie

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1 August 2017

Jonathan M Carlson

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1 August 2017

Martin Markowitz

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1 August 2017

Heiko Jessen

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1 August 2017

language of work or name

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publication date

1 September 2010

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1 August 2017

Journal of Virology

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Europe PubMed Central

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1 August 2017

84

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Europe PubMed Central

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1 August 2017

22

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1 August 2017

11937-11949

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Europe PubMed Central

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1 August 2017

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

1 reference

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6 July 2018

The immune response during acute HIV-1 infection: clues for vaccine development

1 reference

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6 July 2018

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study

1 reference

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6 July 2018

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HIV escape and attenuation by cytotoxic T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

HIV-1 group M conserved elements vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

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A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood

1 reference

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Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Statistical significance for genomewide studies

1 reference

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6 July 2018

The influence of HLA genotype on AIDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Diversity considerations in HIV-1 vaccine selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Escape of human immunodeficiency virus from immune control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

6 July 2018

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

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Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein

1 reference

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6 July 2018

Human immunodeficiency virus variants that escape cytotoxic T-cell recognition

1 reference

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The challenge of HIV-1 subtype diversity.

1 reference

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28 October 2018

Identification of HLA class I-associated amino acid polymorphisms in the HIV-1C proteome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2977869

28 October 2018

Reversion of CTL escape–variant immunodeficiency viruses in vivo

1 reference

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28 October 2018

HIV evolution: CTL escape mutation and reversion after transmission

1 reference

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28 October 2018

Methods for comparing a DNA sequence with a protein sequence.

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28 October 2018

Effects of Human Leukocyte Antigen Class I Genetic Parameters on Clinical Outcomes and Survival after Initiation of Highly Active Antiretroviral Therapy

1 reference

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28 October 2018

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

1 reference

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28 October 2018

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

1 reference

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28 October 2018

Mutations in HIV-1 gag cleavage sites and their association with protease mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA and AIDS: a cautionary tale

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crippling HIV one mutation at a time

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20810731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01086-10

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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