(Q34296136)

1 August 2017

title

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases (English)

1 reference

1 August 2017

1 reference

Chien-Liang Glenn Lin

1

1 reference

1 August 2017

Qiongman Kong

2

1 reference

1 August 2017

Gregory D Cuny

3

1 reference

1 August 2017

Marcie A Glicksman

4

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1 August 2017

language of work or name

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1 September 2012

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Future Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

4

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1 August 2017

issue

13

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1 August 2017

page(s)

1689-1700

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Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

1 August 2017

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6 July 2018

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Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke

6 July 2018

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Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity

6 July 2018

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Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease

6 July 2018

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Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

6 July 2018

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6 July 2018

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Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1.

6 July 2018

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6 July 2018

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6 July 2018

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Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia

6 July 2018

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Astrocytes in the epileptic brain.

6 July 2018

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6 July 2018

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Excitotoxicity and new antiglutamatergic strategies in Parkinson's disease and Alzheimer's disease

6 July 2018

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Progress in neuroprotective strategies for preventing epilepsy.

6 July 2018

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Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies

6 July 2018

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Molecular signaling mechanisms underlying epileptogenesis

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

ALS: a disease of motor neurons and their nonneuronal neighbors

6 July 2018

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Functional changes in astroglial cells in epilepsy

6 July 2018

1 reference

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The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

6 July 2018

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Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Diagnosis and treatment of temporal lobe epilepsy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Glutamate-mediated glial injury: mechanisms and clinical importance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

An astrocytic basis of epilepsy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Extracellular metabolites in the cortex and hippocampus of epileptic patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Functional changes of the basal ganglia circuitry in Parkinson's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Factors affecting excitatory amino acid release following severe human head injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Neurotransmitters in cerebrospinal fluid reflect pathological activity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

MK-801 limits neurovascular dysfunction during experimental allergic encephalomyelitis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Localization of neuronal and glial glutamate transporters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Ionic dependence of glutamate neurotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Regional changes in [3H]D-aspartate and [3H]TCP binding sites in Alzheimer's disease brains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

The functional anatomy of basal ganglia disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Cloning and expression of a rat brain L-glutamate transporter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Primary structure and functional characterization of a high-affinity glutamate transporter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.

6 July 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Antiparkinsonian actions of glutamate antagonists--alone and with L-DOPA: a review of evidence and suggestions for possible mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Astrocyte-neuron interactions: implications for epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Changes in glial glutamate transporters in human epileptogenic hippocampus: inadequate explanation for high extracellular glutamate during seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Glutamate release in severe brain ischaemia is mainly by reversed uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 (EAAT2) Upregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Effects of mild hypothermia on cerebral blood flow-independent changes in cortical extracellular levels of amino acids following contusion trauma in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Early loss of the glutamate transporter splice-variant GLT-1v in rat cerebral cortex following lateral fluid-percussion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Regulation of glial glutamate transporter expression by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3580837

Translational Control of Glial Glutamate Transporter EAAT2 Expression

28 October 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.122

The role of excitatory amino acids and NMDA receptors in traumatic brain injury

21 January 2018

1 reference

12 December 2020

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

1 reference

12 December 2020

Mechanisms of ischemic brain damage

1 reference

12 December 2020

Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry

1 reference

12 December 2020

Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB

1 reference

12 December 2020

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

1 reference

12 December 2020

Identifiers

DOI

10.4155/FMC.12.122

1 reference

1 August 2017

1 reference

1 August 2017

1 reference