(Q34305846)

1 August 2017

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title

The mechanisms of action of commonly used antiepileptic drugs (English)

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1 August 2017

Kwan P

1

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1 August 2017

Sills GJ

series ordinal

2

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1 August 2017

Brodie MJ

series ordinal

3

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1 August 2017

publication date

1 April 2001

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Pharmacology & Therapeutics

1 August 2017

published in

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1 August 2017

volume

90

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1 August 2017

issue

1

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1 August 2017

page(s)

21-34

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Electrophysiologic analysis of the actions of valproate on pyramidal neurons in the rat hippocampal slice.

1 August 2017

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Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission

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Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group

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Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission

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Cellular and molecular biology of voltage-gated sodium channels

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7 January 2021

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7 January 2021

Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content

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7 January 2021

Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose-dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice.

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7 January 2021

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

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Selective antagonism of the anticonvulsant effects of felbamate by glycine

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Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in?

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7 January 2021

Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current.

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7 January 2021

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

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7 January 2021

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

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7 January 2021

Modulated anticonvulsant block of sodium channels in nerve and muscle

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7 January 2021

Compartmentation of brain glutamate metabolism in neurons and glia

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7 January 2021

Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships.

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7 January 2021

Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+.

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7 January 2021

Mechanisms of action of antiepileptic drugs

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7 January 2021

Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons

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7 January 2021

New antiepileptic drugs

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7 January 2021

The G.L. Brown Prize Lecture. Voltage-dependent calcium channels and their modulation by neurotransmitters and G proteins

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7 January 2021

The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.

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7 January 2021

K+ channel openers decrease seizures in genetically epileptic rats

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7 January 2021

The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

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7 January 2021

Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons

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7 January 2021

Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA

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7 January 2021

Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice

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7 January 2021

Cloning and expression of a rat brain GABA transporter

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7 January 2021

Molecular basis for Ca2+ channel diversity

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7 January 2021

GABAA receptor pharmacology

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7 January 2021

gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

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7 January 2021

Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual field defects

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7 January 2021

Effects of zonisamide on K+ and Ca2+ evoked release of monoamine as well as K+ evoked intracellular Ca2+ mobilization in rat hippocampus.

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7 January 2021

Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons

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7 January 2021

GABA uptake inhibitors: relevance to antiepileptic drug research

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7 January 2021

Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones

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7 January 2021

Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications.

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7 January 2021

Early identification of refractory epilepsy

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7 January 2021

Zonisamide for progressive myoclonus epilepsy: long-term observations in seven patients

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

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7 January 2021

Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes.

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7 January 2021

Neurochemical actions of gabapentin in mouse brain.

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7 January 2021

Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action.

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7 January 2021

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7 January 2021

Efficacy and safety of zonisamide: results of a multicenter study.

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7 January 2021

4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain

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7 January 2021

New visions in the pharmacology of anticonvulsion

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7 January 2021

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

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7 January 2021

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

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7 January 2021

The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata.

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7 January 2021

Antiepileptic drug mechanisms of action

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7 January 2021

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture

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7 January 2021

Specific and potent interactions of carbamazepine with brain adenosine receptors

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7 January 2021

ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo

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7 January 2021

Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus

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7 January 2021

Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures

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7 January 2021

Oxcarbazepine: mechanisms of action

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7 January 2021

Neurotransmission in epilepsy.

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7 January 2021

Update on the mechanism of action of antiepileptic drugs

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7 January 2021

Glutamate as a neurotransmitter in the brain: review of physiology and pathology

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7 January 2021

Basic mechanisms of gabitril (tiagabine) and future potential developments

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7 January 2021

Glutamate receptors and transporters in genetic and acquired models of epilepsy

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7 January 2021

Inhibition of delayed rectifier K+ channels by phenytoin in rat neuroblastoma cells

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7 January 2021

The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes

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7 January 2021

Effects of zonisamide on dopaminergic system

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7 January 2021

GABA and epileptogenesis

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7 January 2021

P/Q-type Ca2+ channel defects in migraine, ataxia and epilepsy.

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7 January 2021

Felbamate: 1997 update

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7 January 2021

Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin

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7 January 2021

The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy

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7 January 2021

Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose.

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7 January 2021

Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy

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7 January 2021

Electrophysiological actions of felbamate on rat striatal neurones.

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7 January 2021

Voltage-gated potassium channels: from hyperexcitability to excitement

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7 January 2021

New antiepileptic drugs: from serendipity to rational discovery

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7 January 2021

Effects of the antiepileptic drug felbamate on long-term potentiation in the CA1 region of rat hippocampal slices.

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7 January 2021

From ion currents to genomic analysis: recent advances in GABAA receptor research.

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7 January 2021

Sodium channels as molecular targets for antiepileptic drugs

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7 January 2021

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

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7 January 2021

The pharmacologic basis of antiepileptic drug action

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7 January 2021

Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors

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7 January 2021

Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons

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7 January 2021

Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant

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7 January 2021

Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones

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7 January 2021

KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy

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7 January 2021

D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

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7 January 2021

Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo

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7 January 2021

The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

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7 January 2021

Zonisamide enhances slow sodium inactivation in Myxicola

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7 January 2021

Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors

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7 January 2021

Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity

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7 January 2021

Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy.

1 reference

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7 January 2021

Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers

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7 January 2021

Topiramate: preclinical evaluation of structurally novel anticonvulsant.

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7 January 2021

Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain.

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7 January 2021

Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study

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7 January 2021

Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt

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7 January 2021

Differential block of two types of sodium channels by anticonvulsants.

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7 January 2021

Benzodiazepine receptors in rat brain

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7 January 2021

Effects of felbamate on veratridine- and K(+)-stimulated release of glutamate from mouse cortex.

1 reference

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7 January 2021

Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Voltage-activated calcium channels: targets of antiepileptic drug therapy?

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7 January 2021

The functional states of the thalamus and the associated neuronal interplay

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7 January 2021

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons

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7 January 2021

Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells

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7 January 2021

Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex

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7 January 2021

Felbamate inhibits cloned voltage-dependent Na+ channels from human and rat brain.

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7 January 2021

3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents

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7 January 2021

A summary of mechanistic hypotheses of gabapentin pharmacology

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7 January 2021

Felbamate, a novel antiepileptic drug, reverses N-methyl-D-aspartate/glycine-stimulated increases in intracellular Ca2+ concentration

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

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7 January 2021

Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cord

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7 January 2021

Effect of anticonvulsant felbamate on GABAA receptor system.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Basis of the antiseizure action of phenytoin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Valproate reduces excitability by blockage of sodium and potassium conductance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Felbamate modulates the strychnine-insensitive glycine receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2801%2900122-X

7 January 2021

10.1016/S0163-7258(01)00122-X

Identifiers

DOI

1 reference

1 August 2017

1 reference