(Q34307956)

1 August 2017

title

Guiding principles for natural product drug discovery (English)

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1 August 2017

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Ronald J Quinn

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1 August 2017

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David Camp

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1 August 2017

author name string

Elizabeth A Evans-Illidge

series ordinal

3

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1 August 2017

publication date

1 June 2012

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Future Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

4

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1 August 2017

issue

9

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1 August 2017

page(s)

1067-1084

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

1 August 2017

cites work

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Coexistence of passive and carrier-mediated processes in drug transport

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Pursuing the leadlikeness concept in pharmaceutical research.

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The Role of Hydrophobicity in Toxicity Prediction

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The impact of natural products upon modern drug discovery.

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Natural products and traditional medicine: turning on a paradigm

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Pure compound libraries; a new perspective for natural product based drug discovery

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Modern methods to produce natural-product libraries

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Developing a drug-like natural product library

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Origin and evolution of high throughput screening

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Pre-fractionated microbial samples--the second generation natural products library at Wyeth

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

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Observations on screening-based research and some concerning trends in the literature

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High-throughput method for the production and analysis of large natural product libraries for drug discovery

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Automated high-throughput system to fractionate plant natural products for drug discovery

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Drug-like properties: guiding principles for the design of natural product libraries.

21 January 2018

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Marine natural product libraries for high-throughput screening and rapid drug discovery

21 January 2018

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Natural product libraries to accelerate the high-throughput discovery of therapeutic leads

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Screening in a spirit haunted world

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Apparent activity in high-throughput screening: origins of compound-dependent assay interference

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Impact of high-throughput screening in biomedical research

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Lessons from 60 years of pharmaceutical innovation

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Ligand efficiency: a useful metric for lead selection

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Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras

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Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia

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Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.

21 January 2018

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Antitrypanosomal cyclic polyketide peroxides from the Australian marine sponge Plakortis sp.

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The Rule of Five revisited: applying log D in place of log P in drug-likeness filters

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The price of innovation: new estimates of drug development costs

21 January 2018

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(-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata

21 January 2018

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The evolving role of natural products in drug discovery

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Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

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Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

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A tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation tools

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Natural products as a screening resource

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A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products

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Natural products in drug discovery

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Grand challenge commentary: Beyond discovery: probes that see, grab and poke

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Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening

21 January 2018

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A Simple Method for High-Throughput Extract Prefractionation for Biological Screening

21 January 2018

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(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp

21 January 2018

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Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum

21 January 2018

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Pseudoceratinazole A: a novel bromotyrosine alkaloid from the Australian sponge Pseudoceratina sp

21 January 2018

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Endiandrin A, a Potent Glucocorticoid Receptor Binder Isolated from the Australian PlantEndiandraanthropophagorum

21 January 2018

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Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation

21 January 2018

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.36.1279

Identifiers

DOI

10.4155/FMC.12.55

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1 August 2017

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