(Q34314503)

25228770

1 August 2017

title

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane (English)

1 reference

1 August 2017

0 references

5

1 reference

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2 June 2020

Brian J. Smith

9

1 reference

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2 June 2020

Jerry Adams

10

1 reference

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2 June 2020

Ruth Kluck

11

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2 June 2020

author name string

Dana Westphal

1

1 reference

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2 June 2020

Grant Dewson

2

1 reference

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2 June 2020

Marie Menard

3

1 reference

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2 June 2020

Paul Frederick

4

1 reference

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2 June 2020

Ray Bartolo

6

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2 June 2020

Leonie Gibson

7

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2 June 2020

Peter E Czabotar

8

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2 June 2020

language of work or name

English

0 references

publication date

16 September 2014

1 reference

25228770

Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25228770%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

111

1 reference

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2 June 2020

issue

39

1 reference

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2 June 2020

page(s)

E4076-85

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25228770%20AND%20SRC:MED&resulttype=core&format=json

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

2 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

BID-induced structural changes in BAK promote apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bak apoptotic function is not directly regulated by phosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

The secrets of the Bcl-2 family

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Pores formed by Baxα5 relax to a smaller size and keep at equilibrium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

6 July 2018

The BCL-2 family reunion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Assembly of the mitochondrial apoptosis-induced channel, MAC.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Topology of transmembrane proteins by scanning cysteine accessibility mutagenesis methodology.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Pore-forming protein toxins: from structure to function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Structure of Bax: coregulation of dimer formation and intracellular localization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Biochemical and genetic evidence for three transmembrane domains in the class I holin, lambda S.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

Conformation of the Bax C-terminus regulates subcellular location and cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191798

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

Molecular details of Bax activation, oligomerization, and membrane insertion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1415142111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1415142111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25228770%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25228770%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

25228770

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25228770%20AND%20SRC:MED&resulttype=core&format=json