(Q34322013)

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Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha

scientific article published on October 8, 2010

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Europe PubMed Central

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1 August 2017

Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha (English)

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Europe PubMed Central

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1 August 2017

Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha (English)

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10.1093/TOXSCI/KFQ280

https://api.crossref.org/works/10.1093/TOXSCI/KFQ280

30 July 2024

enzymologic gene expression regulation

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

Frank J. Gonzalez

2

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Frank J. Gonzalez

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

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Hong Lu

1

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1 August 2017

Curtis Klaassen

3

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1 August 2017

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National Center for Biotechnology Information

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20935164

30 July 2024

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8 October 2010

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1 August 2017

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https://academic.oup.com/toxsci/article-pdf/118/2/380/16682363/kfq280.pdf

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30 July 2024

http://toxsci.oxfordjournals.org/cgi/content/abstract/118/2/380

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Europe PubMed Central

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30 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20935164/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20935164/pdf/?tool=EBI

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30 July 2024

https://europepmc.org/articles/PMC2984525

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

https://europepmc.org/articles/PMC2984525?pdf=render

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

https://doi.org/10.1093/toxsci/kfq280

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20935164

30 July 2024

http://academic.oup.com/toxsci/article-pdf/118/2/380/16682363/kfq280.pdf

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10.1093/TOXSCI/KFQ280

https://api.crossref.org/works/10.1093/TOXSCI/KFQ280

30 July 2024

Toxicological Sciences

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Europe PubMed Central

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1 August 2017

118

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Europe PubMed Central

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1 August 2017

2

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Europe PubMed Central

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1 August 2017

380-390

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Europe PubMed Central

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1 August 2017

Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements

1 reference

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Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1

1 reference

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Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha.

1 reference

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Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha

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Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.

1 reference

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Very important pharmacogene summary: sulfotransferase 1A1.

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Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa

1 reference

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6 July 2018

Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase.

1 reference

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Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation

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6 July 2018

Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers

1 reference

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6 July 2018

Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

1 reference

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6 July 2018

Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

SVCT1 and SVCT2: key proteins for vitamin C uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles

1 reference

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6 July 2018

Specificity and regulation of renal sulfate transporters

1 reference

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6 July 2018

HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression

1 reference

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6 July 2018

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

1 reference

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Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction

1 reference

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Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b

1 reference

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6 July 2018

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

6 July 2018

Regulation of hepatic transporters by xenobiotic receptors

1 reference

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6 July 2018

Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha

1 reference

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6 July 2018

Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice

1 reference

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6 July 2018

Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels

1 reference

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6 July 2018

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors

1 reference

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6 July 2018

Control of pancreas and liver gene expression by HNF transcription factors

1 reference

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Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

1 reference

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Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus

1 reference

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6 July 2018

Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo

1 reference

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1 reference

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1 reference

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1 reference

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6 July 2018

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1 reference

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1 reference

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6 July 2018

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1 reference

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6 July 2018

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

1 reference

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6 July 2018

Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1.

1 reference

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6 July 2018

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1 reference

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6 July 2018

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1 reference

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6 July 2018

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1 reference

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6 July 2018

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1 reference

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6 July 2018

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1 reference

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6 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions

1 reference

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28 October 2018

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

1 reference

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28 October 2018

Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport

1 reference

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28 October 2018

Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Development of a fluorescent microsphere-based multiplexed high-throughput assay system for profiling of transcription factor activation

1 reference

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28 October 2018

Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Tissue distribution and ontogeny of sulfotransferase enzymes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Tissue distribution and ontogeny of organic cation transporters in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Prediction of nuclear hormone receptor response elements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Hepatocyte Nuclear Factor 4α Is a Central Regulator of Bile Acid Conjugation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Expression of Wilms' tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

C/EBPalpha is a regulator of the UDP glucuronosyltransferase UGT2B1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2984525

28 October 2018

Pregnane X receptor is a target of farnesoid X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20935164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20935164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20935164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe hypoxia specifically downregulates hepatocyte nuclear factor-4 gene expression in HepG2 human hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20935164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/TOXSCI/KFQ280

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

0 references

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