(Q34340172)

1 August 2017

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title

Morphine-6-glucuronide: an analgesic of the future? (English)

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1 August 2017

J Lötsch

1

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author name string

G Geisslinger

series ordinal

2

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1 August 2017

1 January 2001

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Clinical Pharmacokinetics

1 August 2017

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1 August 2017

40

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1 August 2017

7

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1 August 2017

485-499

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https://scigraph.springernature.com/pub.10.2165/00003088-200140070-00001

1 August 2017

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Morphine and morphine-6-glucuronide plasma concentrations and effect in cancer pain.

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Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat

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Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action

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Systematic review of factors affecting the ratios of morphine and its major metabolites

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Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats.

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Morphine-6-glucuronide is more mu-selective and potent in analgesic tests than morphine.

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12 December 2020

Clinical pharmacokinetics of morphine

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12 December 2020

The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive‐care patients

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12 December 2020

Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum

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12 December 2020

Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: plasma profiles, steady-state concentrations and the consequences of renal failure

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12 December 2020

Analgesic Effect of Morphine Glucuronides

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12 December 2020

Narcotic Analgesics in Anuric Patients

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12 December 2020

Effects of naltrexone on pharmacodynamics and pharmacokinetics of intravenously administered morphine in the rat

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12 December 2020

Natural (-)- and unnatural (+)-enantiomers of morphine: comparative metabolism and effect of morphine and phenobarbital treatment

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12 December 2020

Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

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12 December 2020

Hepatic extraction of morphine is impaired in cirrhosis

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12 December 2020

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

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12 December 2020

Lack of Analgesic Activity of Morphine-6-glucuronide after Short-term Intravenous Administration in Healthy Volunteers

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12 December 2020

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12 December 2020

Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium

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12 December 2020

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

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12 December 2020

The analgesic activity of morphine-6-glucuronide

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12 December 2020

Analgesic activity of morphine-6-glucuronide

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12 December 2020

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12 December 2020

Extrahepatic morphine metabolism in man during the anhepatic phase of orthotopic liver transplantation.

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12 December 2020

Morphine-6-glucuronide might mediate the prolonged opioid effect of morphine in acute renal failure

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12 December 2020

Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain.

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12 December 2020

Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration

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12 December 2020

Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

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12 December 2020

Human UGT2B7 catalyzes morphine glucuronidation

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12 December 2020

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12 December 2020

Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)

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12 December 2020

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

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12 December 2020

Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms.

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12 December 2020

Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3

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12 December 2020

Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein

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12 December 2020

Morphine intoxication in renal failure: the role of morphine-6-glucuronide

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12 December 2020

Chronic nausea and morphine-6-glucuronide

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12 December 2020

Preemptive intravenous morphine-6-glucuronide is ineffective for postoperative pain relief

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12 December 2020

Pharmacokinetic-pharmacodynamic relationships for analgesics.

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12 December 2020

Pharmacokinetics of morphine in patients following orthotopic liver transplantation.

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12 December 2020

Morphine metabolism in neonates and infants

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12 December 2020

Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor

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12 December 2020

Ethanol interference with morphine metabolism in isolated guinea pig hepatocytes

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12 December 2020

Multiple mu opiate receptors

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12 December 2020

The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

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12 December 2020

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

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12 December 2020

Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.

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12 December 2020

M6G and its analgesic action in chronic use

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12 December 2020

Octanol−, Chloroform−, and Propylene Glycol Dipelargonat−Water Partitioning of Morphine-6-glucuronide and Other Related Opiates†

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12 December 2020

Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers

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12 December 2020

Analgesic responses to intrathecal morphine in relation to CSF concentrations of morphine-3,beta-glucuronide and morphine-6,beta-glucuronide

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12 December 2020

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity.

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12 December 2020

Intestinal absorption and stability of morphine 6-glucuronide in different physiological compartments of the rat

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12 December 2020

Morphine and morphine metabolite concentrations in cerebrospinal fluid and plasma in cancer pain patients after slow-release oral morphine administration

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12 December 2020

Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling

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12 December 2020

Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

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12 December 2020

Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide

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12 December 2020

Explanation for potency of repeated oral doses of morphine?

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12 December 2020

The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function

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12 December 2020

Morphine-6-glucuronide contributes to rewarding effects of opiates.

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12 December 2020

Chronic morphine therapy for cancer pain: plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations.

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12 December 2020

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat

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12 December 2020

Morphine metabolism in children

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12 December 2020

Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine

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12 December 2020

Morphine metabolism in acutely ill preterm newborn infants

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12 December 2020

Randomized placebo-controlled trial of the activity of the morphine glucuronides

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12 December 2020

Sedation in intensive care: morphine and renal function

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12 December 2020

Mu receptor binding of some commonly used opioids and their metabolites

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12 December 2020

Formation and clearance of active and inactive metabolites of opiates in humans

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12 December 2020

Concentration-effect relationships of morphine and morphine-6 beta-glucuronide in the rat.

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12 December 2020

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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12 December 2020

Morphine-6-glucuronide disposition in renal impairment.

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12 December 2020

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

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12 December 2020

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

1 reference

12 December 2020

Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.

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12 December 2020

Disposition of morphine-6-glucuronide and morphine in healthy volunteers

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12 December 2020

A comparison of intrathecal morphine-6-glucuronide and intrathecal morphine sulfate as analgesics for total hip replacement

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12 December 2020

Normal metabolism of morphine in cirrhosis

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12 December 2020

Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity

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12 December 2020

Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*

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12 December 2020

Dose-dependency of intra-articular morphine analgesia

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12 December 2020

3H-morphine-6beta-glucuronide binding in brain membranes and an MOR-1-transfected cell line.

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12 December 2020

Modulation of morphine-6-glucuronide penetration into the brain by P-glycoprotein.

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12 December 2020

Differential inhibition of hepatic morphine UDP-glucuronosyltransferases by metal ions

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12 December 2020

Physiological disposition of i.v. morphine in sheep.

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12 December 2020

Incomplete cross tolerance and multiple mu opioid peptide receptors

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12 December 2020

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12 December 2020

Morphine glucuronidation in premature neonates

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12 December 2020

Morphine, morphine-6-glucuronide and morphine-3-glucuronide concentrations in plasma and cerebrospinal fluid during long-term high-dose intrathecal morphine administration.

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12 December 2020

Pharmacological mechanisms of opioid analgesics.

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12 December 2020

Respiratory depression following morphine and morphine-6-glucuronide in normal subjects.

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12 December 2020

Concentrations of morphine and morphine metabolites in CSF and plasma during continuous subcutaneous morphine administration in cancer pain patients.

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12 December 2020

Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception

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12 December 2020

Extrahepatic metabolism of morphine occurs in humans

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12 December 2020

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis

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12 December 2020

A pharmacodynamic model for pancuronium

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12 December 2020

Potential analgesic contribution from morphine-6-glucuronide in CSF

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12 December 2020

Morphine-6-glucuronide concentrations and opioid-related side effects: a survey in cancer patients

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12 December 2020

Morphine-6-glucuronide, an important metabolite

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12 December 2020

Human brain metabolism of morphine and naloxone

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12 December 2020

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

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12 December 2020

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

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12 December 2020

Pharmacokinetics of morphine infusion in premature neonates

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12 December 2020

Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

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12 December 2020

Analgesic response and plasma and brain extracellular fluid pharmacokinetics of morphine and morphine-6-beta-D-glucuronide in the rat

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12 December 2020

Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine

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12 December 2020

Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene

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12 December 2020

Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients--a comparison of two oral formulations

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12 December 2020

Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children

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12 December 2020

Chronic ethanol consumption causes increased glucuronidation of morphine in rabbits

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12 December 2020

10.2165/00003088-200140070-00001

Identifiers

DOI

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PubMed ID

11510626

Dimensions Publication ID

1 August 2017

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1 reference

PubMed ID

11510626