(Q34347566)

English

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

1 reference

based on heuristic

inferred from title

author name string

R C Halliday

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

B C Jones

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

D A Smith

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

N R Kitteringham

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

B K Park

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

0 references

publication date

1 October 1995

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

40

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

369-378

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Selective inhibitors of cytochromes P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

The pharmacogenetics of the selective serotonin reuptake inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Cardiac effect of halofantrine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Immunoblotting and dot immunobinding — Current status and outlook

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

A dose-effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Molecular genetics of the debrisoquin-sparteine polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Human cytochromes P450: problems and prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Halofantrine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

6 July 2018

Cardiac effects of antimalarial treatment with halofantrine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04559.X

21 January 2018

Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04559.X

21 January 2018

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04559.X

21 January 2018

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365156

27 October 2018

Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of halofantrine and its principal metabolite desbutylhalofantrine in biological fluids by reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of the contraceptive steroid desogestrel by human liver in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

49 Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of halofantrine and its major metabolite desbutylhalofantrine in plasma and blood by high-performance liquid chromatography: a new methodology

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/8554939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.1995.TB04559.X

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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