(Q34351999)

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Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug

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Europe PubMed Central

PubMed publication ID

1 August 2017

Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Plasmodium falciparum

0 references

Trypanosoma evansi

object named as

Trypanosoma evansi

1 reference

based on heuristic

inferred from title

Pinaki Talukdar

object named as

Pinaki Talukdar

4

0 references

object named as

Utpal Tatu

12

0 references

author name string

Rani Pallavi

1

1 reference

Europe PubMed Central

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1 August 2017

Nainita Roy

2

1 reference

Europe PubMed Central

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1 August 2017

Rishi Kumar Nageshan

3

1 reference

Europe PubMed Central

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1 August 2017

Soundara Raghavan Pavithra

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Raghunath Reddy

6

1 reference

Europe PubMed Central

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1 August 2017

S Venketesh

7

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Rajender Kumar

8

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Ashok Kumar Gupta

9

1 reference

Europe PubMed Central

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1 August 2017

Raj Kumar Singh

10

1 reference

Europe PubMed Central

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1 August 2017

Suresh Chandra Yadav

11

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1 August 2017

language of work or name

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publication date

13 September 2010

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Europe PubMed Central

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1 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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1 August 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

49

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

37964-37975

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Proteomics of Trypanosoma evansi infection in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

17 AAG for HSP90 inhibition in cancer--from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

The charged linker region is an important regulator of Hsp90 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

A phase II trial of 17-allylamino-17- demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Hsp90: the vulnerable chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Recurrent fever promotes Plasmodium falciparum development in human erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Hsp70 and Hsp90--a relay team for protein folding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Molecular chaperones--cellular machines for protein folding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Inhibition of HSP90 in Trypanosoma cruzi induces a stress response but no stage differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Hsp90 as a capacitor of phenotypic variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Hsp90 as a capacitor for morphological evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992230

6 July 2018

Rho-modifying C3-like ADP-ribosyltransferases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Hsp90 is essential in the filarial nematode Brugia pahangi

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.155317

21 January 2018

Nucleotides and two functional states of hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/20837488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmodium falciparum: Assessment of in vitro growth by [3H]hypoxanthine incorporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20837488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.155317

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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