(Q34358104)

1 August 2017

title

Drug-induced long QT syndrome (English)

1 reference

1 August 2017

Drug-Induced Long QT Syndrome (English)

1 reference

Crossref

DOI

10.1124/PR.110.003723

https://api.crossref.org/works/10.1124/PR.110.003723

27 August 2024

1 reference

adverse drug reaction

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

27 August 2024

2

Dan M Roden

1 reference

1 August 2017

3

Dawood Darbar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

27 August 2024

author name string

Prince Kannankeril

series ordinal

1

1 reference

1 August 2017

Dan M. Roden

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

27 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21079043

27 August 2024

publication date

1 December 2010

1 reference

full work available at URL

1 August 2017

https://europepmc.org/articles/pmc2993258?pdf=render

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

http://pharmrev.aspetjournals.org/cgi/content/abstract/62/4/760

27 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21079043/?tool=EBI

27 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21079043/pdf/?tool=EBI

27 August 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://europepmc.org/articles/PMC2993258

27 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://europepmc.org/articles/PMC2993258?pdf=render

27 August 2024

file format

Portable Document Format

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://doi.org/10.1124/pr.110.003723

27 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21079043

https://syndication.highwire.org/content/doi/10.1124/pr.110.003723

27 August 2024

1 reference

Crossref

DOI

10.1124/PR.110.003723

https://api.crossref.org/works/10.1124/PR.110.003723

27 August 2024

published in

Pharmacological Reviews

1 reference

1 August 2017

volume

62

1 reference

1 August 2017

issue

4

1 reference

1 August 2017

page(s)

760-781

1 reference

Identification of a Kir3.4 mutation in congenital long QT syndrome

1 August 2017

cites work

1 reference

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Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

6 July 2018

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Genome-wide association study identifies eight loci associated with blood pressure

6 July 2018

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Common variants at ten loci modulate the QT interval duration in the QTSCD Study

6 July 2018

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The effect of moxifloxacin on QTc and implications for the design of thorough QT studies

6 July 2018

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Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations

6 July 2018

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Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study

6 July 2018

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A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers

6 July 2018

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Model systems for the discovery and development of antiarrhythmic drugs.

6 July 2018

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hERG (KCNH2 or Kv11.1) K+ channels: screening for cardiac arrhythmia risk

6 July 2018

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Drug-induced spatial dispersion of repolarization

6 July 2018

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Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

6 July 2018

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The hERG potassium channel and hERG screening for drug-induced torsades de pointes

6 July 2018

1 reference

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Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

6 July 2018

1 reference

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Drug-induced long QT syndrome in women: review of current evidence and remaining gaps

6 July 2018

1 reference

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The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes

6 July 2018

1 reference

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The canine model with chronic, complete atrio-ventricular block

6 July 2018

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Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

6 July 2018

1 reference

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Impact of baseline ECG collection on the planning, analysis and interpretation of 'thorough' QT trials

6 July 2018

1 reference

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Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: a database review and analysis

6 July 2018

1 reference

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Preclinical assessment of drug-induced proarrhythmias: role of the arterially perfused rabbit left ventricular wedge preparation

6 July 2018

1 reference

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CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart

6 July 2018

1 reference

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Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome

6 July 2018

1 reference

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Mutation of an A-kinase-anchoring protein causes long-QT syndrome

6 July 2018

1 reference

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Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

6 July 2018

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Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits

6 July 2018

1 reference

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Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event

6 July 2018

1 reference

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SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome

6 July 2018

1 reference

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Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.

6 July 2018

1 reference

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Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes

6 July 2018

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Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion

6 July 2018

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Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

6 July 2018

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No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.

6 July 2018

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Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

6 July 2018

1 reference

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A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

6 July 2018

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Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

6 July 2018

1 reference

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The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels

6 July 2018

1 reference

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A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

6 July 2018

1 reference

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Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs

6 July 2018

1 reference

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Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

6 July 2018

1 reference

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Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents

6 July 2018

1 reference

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Drug-induced torsades de pointes: the evolving role of pharmacogenetics

6 July 2018

1 reference

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Drugs, QTc interval prolongation and final ICH E14 guideline : an important milestone with challenges ahead

6 July 2018

1 reference

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Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve

6 July 2018

1 reference

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Genetics of acquired long QT syndrome

6 July 2018

1 reference

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Drug-induced QT interval prolongation--regulatory guidance and perspectives on hERG channel studies.

6 July 2018

1 reference

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Use of in vitro methods to predict QT prolongation

6 July 2018

1 reference

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Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

6 July 2018

1 reference

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Pentamidine reduces hERG expression to prolong the QT interval

6 July 2018

1 reference

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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

6 July 2018

1 reference

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Drug-induced torsades de pointes and implications for drug development.

6 July 2018

1 reference

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When u say "U Waves," what do u mean?

6 July 2018

1 reference

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SUDDEN DEATH DURING TREATMENT WITH PHENOTHIAZINE DERIVATIVES.

6 July 2018

1 reference

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QUINIDINE SYNCOPE. PAROXYSMAL VENTRICULAR FIBRILLATION OCCURRING DURING TREATMENT OF CHRONIC ATRIAL ARRHYTHMIAS.

6 July 2018

1 reference

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RARE CARDIAC ARRYTHMIAS OF THE PEDIATRIC AGE. II. SYNCOPAL ATTACKS DUE TO PAROXYSMAL VENTRICULAR FIBRILLATION. (PRESENTATION OF 1ST CASE IN ITALIAN PEDIATRIC LITERATURE)

6 July 2018

1 reference

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A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN

6 July 2018

1 reference

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Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death

6 July 2018

1 reference

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Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

6 July 2018

1 reference

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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

6 July 2018

1 reference

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Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

6 July 2018

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A comparison of rate control and rhythm control in patients with atrial fibrillation

6 July 2018

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Torsade de pointes associated with very-high-dose methadone

6 July 2018

1 reference

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Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block

6 July 2018

1 reference

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Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

6 July 2018

1 reference

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Increased atrial fibrillation mortality: United States, 1980-1998.

6 July 2018

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Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

6 July 2018

1 reference

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Electrical heterogeneity within the ventricular wall

6 July 2018

1 reference

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Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy

6 July 2018

1 reference

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Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

6 July 2018

1 reference

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Mechanisms of action of class III agents and their clinical relevance.

6 July 2018

1 reference

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A structural basis for drug-induced long QT syndrome

6 July 2018

1 reference

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A common polymorphism associated with antibiotic-induced cardiac arrhythmia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

6 July 2018

1 reference

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Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia

6 July 2018

1 reference

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Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de Pointes in models of acquired and congenital long QT syndrome.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Sotalol: An important new antiarrhythmic

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Torsade de pointes induced by cisapride/clarithromycin interaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

KCNE1 mutations cause jervell and Lange-Nielsen syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Combined use of astemizole and ketoconazole resulting in torsade de pointes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Ibutilide Repeat Dose Study Investigators

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Use of terfenadine and contraindicated drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Cellular basis for the electrocardiographic J wave

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Antiarrhythmic drugs and torsade de pointes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Proarrhythmic effects of a quinidine analog in dogs with chronic A-V block

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Death Associated With Ventricular Arrhythmia and Thioridazine Hydrochloride

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

The long QT syndrome and syncope caused by spike torsades

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Ventricular tachycardia with 2 variable opposing foci

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Effects of quinidine on plateau currents of guinea-pig ventricular myocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Treatment of torsade de pointes with magnesium sulfate.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Amiodarone and torsade de pointes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Magnesium treatment of ventricular arrhythmias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Cardiotoxic effect with convulsions in terfenadine overdose

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Quinidine delays IK activation in guinea pig ventricular myocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Clinical safety profile of sotalol in patients with arrhythmias

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Dysrhythmia associated with fluoxetine treatment in an elderly patient with cardiac disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Torsades de pointes occurring in association with terfenadine use

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Sex differences in the evolution of the electrocardiographic QT interval with age

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Quinidine syncope: torsade de pointes with low quinidine plasma concentrations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Repolarization reserve: a moving target

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Moxifloxacin-induced torsades de pointes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Cardiac sodium channel gene variants and sudden cardiac death in women

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

A rate-independent method of assessing QT-RR slope following conversion of atrial fibrillation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Reverse remodeling of the left cardiac chambers after catheter ablation after 1 year in a series of patients with isolated atrial fibrillation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Pentamidine-induced long QT syndrome and block of hERG trafficking

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Mechanisms of arsenic-induced prolongation of cardiac repolarization

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Metabolic products of the cinchona alkaloids in human urine.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Physicochemical features of the HERG channel drug binding site

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Proarrhythmic effects of intravenous quinidine, amiodarone, D-sotalol, and almokalant in the anesthetized rabbit model of torsade de pointes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Effects of ionic remodeling on cardiac antiarrhythmic drug actions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Drug block of I(kr): model systems and relevance to human arrhythmias

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

The pause that refreshes, or does it? Mechanisms in torsades de pointes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Modulation of cardiac inward rectifier K(+)current by halothane and isoflurane

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Gender difference in the cycle length-dependent QT and potassium currents in rabbits

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Fluoxetine and ventricular torsade — is there a link?

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Giant T–U Waves Precede Torsades de Pointes in Long QT Syndrome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993258

Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling

9 December 2018

1 reference

12 December 2020

Near-thorough QT study as part of a first-in-man study

1 reference

12 December 2020

Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve

1 reference

12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

1 reference

12 December 2020

QT interval prolongation as predictor of sudden death in patients with myocardial infarction

1 reference

12 December 2020

Exaggerated QT prolongation after cardioversion of atrial fibrillation

1 reference

12 December 2020

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability

1 reference

12 December 2020

N-Acetyl procainamide causing torsades de pointes

1 reference

12 December 2020

Observations on the onset of torsade de pointes arrhythmias in the acquired long QT syndrome

1 reference

12 December 2020

Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

1 reference

12 December 2020

Low penetrance in the long-QT syndrome: clinical impact

1 reference

12 December 2020

Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue

1 reference

12 December 2020

The differential effect of quinidine and pyrilamine on the myocardial action potential at various rates of stimulation

1 reference

12 December 2020

Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation

1 reference

12 December 2020

An underrecognized challenge in evaluating postmarketing drug safety

1 reference

12 December 2020

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

12 December 2020

Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin

1 reference

12 December 2020

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

1 reference

12 December 2020

Comparative in vitro electrophysiology of quinidine, its major metabolites and dihydroquinidine

1 reference

12 December 2020

Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients

1 reference

12 December 2020

Moxifloxacin and torsade de pointes

1 reference

12 December 2020

Quinidine-induced inhibition of transient outward current in cardiac muscle

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1 reference

12 December 2020

In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide

1 reference

12 December 2020

Frequency-dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers

1 reference

12 December 2020

Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current

1 reference

12 December 2020

Acceleration-induced action potential prolongation and early afterdepolarizations

1 reference

12 December 2020

Torsade de pointes induced by N-Acetylprocainamide

1 reference

12 December 2020

[Torsade de pointes after poisoning with fluoxetine alone]

1 reference

12 December 2020

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

12 December 2020

Polymorphous ventricular tachycardia and atrioventricular block

1 reference

12 December 2020

Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes

1 reference

12 December 2020

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients

1 reference

12 December 2020

Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence

1 reference

12 December 2020

There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle

1 reference

12 December 2020

Torsade de pointes ventricular tachycardia associated with astemizole overdose

1 reference

12 December 2020

Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations

1 reference

12 December 2020

The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada

1 reference

12 December 2020

Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome

1 reference

12 December 2020

KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome

1 reference

12 December 2020

Efficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine

1 reference

12 December 2020

Pharmacies and prevention of potentially fatal drug interactions

1 reference

12 December 2020

A sensitive mechanism for cation modulation of potassium current

1 reference

12 December 2020

Delayed sodium channel inactivation mimics long QT syndrome 3

1 reference

12 December 2020

Computer aided development of antiarrhythmic agents with class IIIa properties

1 reference

12 December 2020

Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis

1 reference

12 December 2020

Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant

1 reference

12 December 2020

Drug labeling revisions-guaranteed to fail?

1 reference

12 December 2020

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1 reference

12 December 2020

Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

1 reference

12 December 2020

Identifiers

DOI

10.1124/PR.110.003723

1 reference

1 August 2017

1 reference

1 August 2017

1 reference