(Q45970514)

18 December 2017

title

Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. (English)

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18 December 2017

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Hsien C Cheng

1

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18 December 2017

Josephine Incardona

series ordinal

2

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18 December 2017

publication date

11 June 2009

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18 December 2017

Journal of Pharmacological and Toxicological Methods

published in

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18 December 2017

volume

60

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18 December 2017

issue

2

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18 December 2017

page(s)

174-184

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18 December 2017

Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes

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Effects of antipsychotic drugs on I(to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis

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Effects of class III antiarrhythmic agents in an in vitro rabbit model of spontaneous torsades de pointe

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An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia

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Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns

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Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

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Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration

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Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans

7 January 2021

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Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation

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RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

7 January 2021

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2

7 January 2021

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Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes

7 January 2021

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Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

7 January 2021

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Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

7 January 2021

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Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2009.05.010

Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2009.05.010

Drug block of I(kr): model systems and relevance to human arrhythmias

7 January 2021

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KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias

7 January 2021

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Detection of proarrhythmia in the female rabbit heart: blinded validation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2009.05.010

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2009.05.010

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18 December 2017

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18 December 2017