(Q34372919)

1 August 2017

title

Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease (English)

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1 August 2017

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5

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1 August 2017

Michel Modo

6

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author name string

Gehan El-Akabawy

1

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1 August 2017

Ivan Rattray

2

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1 August 2017

Saga M Johansson

3

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1 August 2017

Richard Gale

4

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1 August 2017

language of work or name

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9 August 2012

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1 August 2017

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1 August 2017

volume

13

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1 August 2017

page(s)

97

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Therapeutic advances in the management of Huntington's disease.

1 August 2017

cites work

1 reference

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Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.

6 July 2018

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Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

6 July 2018

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6 July 2018

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Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice

6 July 2018

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Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease

6 July 2018

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The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

6 July 2018

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Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease

6 July 2018

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Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline

6 July 2018

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Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease.

6 July 2018

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Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images

6 July 2018

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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

6 July 2018

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Convection-enhanced delivery in the treatment of epilepsy

6 July 2018

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Medium spiny neurons for transplantation in Huntington's disease

6 July 2018

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The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease

6 July 2018

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Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.

6 July 2018

1 reference

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Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.

6 July 2018

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Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions

6 July 2018

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Making stem cell lines suitable for transplantation.

6 July 2018

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Pharmacologically active microcarriers releasing glial cell line - derived neurotrophic factor: Survival and differentiation of embryonic dopaminergic neurons after grafting in hemiparkinsonian rats

6 July 2018

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Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease.

6 July 2018

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A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke

6 July 2018

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Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Transplanted hNT cells ("LBS neurons") in a rat model of huntington's disease: good survival, incomplete differentiation, and limited functional recovery.

6 July 2018

1 reference

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Standardization and statistical approaches to therapeutic trials in the R6/2 mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Stem cells: prospects for functional repair of brain damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Neurological abnormalities in a knock-in mouse model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Conditionally immortalized, multipotential and multifunctional neural stem cell lines as an approach to clinical transplantation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Neural transplantation of human neuroteratocarcinoma (hNT) neurons into ischemic rats. A quantitative dose-response analysis of cell survival and behavioral recovery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. II. Correlation between positron emission tomography and reaching behaviour.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. I. Morphological characteristics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Human neural stem cell transplants improve motor function in a rat model of Huntington's disease

6 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Pharmacological MRI of stem cell transplants in the 3-nitropropionic acid-damaged striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

GABAergic neurons from mouse embryonic stem cells possess functional properties of striatal neurons in vitro, and develop into striatal neurons in vivo in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Microglia density decreases with age in a mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington's disease: morphological and behavioral outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Tenascin-R promotes neuronal differentiation of embryonic stem cells and recruitment of host-derived neural precursor cells after excitotoxic lesion of the mouse striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

In vivo evaluation of pharmacologically active microcarriers releasing nerve growth factor and conveying PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Striatal transplantation in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

A pharmacological MRI assessment of dizocilpine (MK-801) in the 3-nitroproprionic acid-lesioned rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-13-97

Assessment of Motor Coordination and Balance in Mice Using the Rotarod, Elevated Bridge, and Footprint Tests.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Volume and differentiation of striatal grafts in rats: relationship to the number of cells implanted.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3502570

Neural differentiation from human embryonic stem cells in a defined adherent culture condition

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22876937

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2202-13-97

1 reference

Dimensions Publication ID

1 August 2017

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1 reference

1 August 2017

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