(Q34378429)

1 August 2017

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title

Methylation and colorectal cancer (English)

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1 August 2017

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3

Quirke P

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1 August 2017

Jubb AM

1

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PubMed ID

11568897

1 August 2017

Bell SM

series ordinal

2

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1 August 2017

1 September 2001

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1 August 2017

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1 August 2017

195

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1 August 2017

111-134

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1 August 2017

1

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1 August 2017

Cancer statistics, 1996.

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A genetic model for colorectal tumorigenesis

21 January 2018

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Lessons from hereditary colorectal cancer

21 January 2018

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21 January 2018

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Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

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CpG island methylator phenotype in colorectal cancer

21 January 2018

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DNA methylation and gastrointestinal malignancies: functional consequences and clinical implications

21 January 2018

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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

21 January 2018

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ABC of colorectal cancer: Epidemiology

21 January 2018

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Colon cancer: a review of the epidemiology

21 January 2018

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ABC of colorectal cancer. Molecular basis for risk factors

21 January 2018

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Genetic pathways in colorectal and other cancers

21 January 2018

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The mutation rate and cancer

21 January 2018

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A mathematical model for the age distribution of cancer in man

21 January 2018

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The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis

21 January 2018

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CpG-rich islands and the function of DNA methylation

21 January 2018

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Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer

21 January 2018

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CpG islands in vertebrate genomes

21 January 2018

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The essentials of DNA methylation

21 January 2018

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The inheritance of epigenetic defects

21 January 2018

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

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Role for DNA methylation in genomic imprinting

21 January 2018

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Gene number, noise reduction and biological complexity

21 January 2018

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Mobile elements and the human genome

21 January 2018

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Methylation-induced repression--belts, braces, and chromatin

21 January 2018

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Repeat-induced gene silencing in mammals.

21 January 2018

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Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis

21 January 2018

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DNA hypomethylation leads to elevated mutation rates

21 January 2018

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DNA methylation and genetic instability in colorectal cancer cells

21 January 2018

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Patterns of methylation of the c-myc gene in human colorectal cancer progression

21 January 2018

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The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia

21 January 2018

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DNA methylation: a molecular lock

21 January 2018

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Cancer epigenetics comes of age

21 January 2018

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Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control

21 January 2018

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Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens

21 January 2018

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The influence of age on colonic epithelial cell proliferation

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

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DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines

21 January 2018

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MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

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High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

21 January 2018

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Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

21 January 2018

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Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers

21 January 2018

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Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

21 January 2018

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

21 January 2018

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Nucleosome assembly on methylated CGG triplet repeats in the fragile X mental retardation gene 1 promoter.

21 January 2018

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CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

21 January 2018

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Relationships between chromatin organization and DNA methylation in determining gene expression

21 January 2018

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

21 January 2018

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Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

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DNA methylation directs a time-dependent repression of transcription initiation.

21 January 2018

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Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene

21 January 2018

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What's up and down with histone deacetylation and transcription?

21 January 2018

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

21 January 2018

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

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Transcriptional coregulators in development.

21 January 2018

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Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

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DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

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The DNA methyltransferases of mammals

21 January 2018

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

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De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

21 January 2018

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A mammalian protein with specific demethylase activity for mCpG DNA.

21 January 2018

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DNA methylation is a reversible biological signal

21 January 2018

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High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer

21 January 2018

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Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

21 January 2018

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Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

21 January 2018

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Suppression of intestinal neoplasia by DNA hypomethylation.

21 January 2018

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Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

21 January 2018

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Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

21 January 2018

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Role of DNA 5-methylcytosine transferase in cell transformation by fos

21 January 2018

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Regulation of DNA methylation by the Ras signaling pathway

21 January 2018

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CpG methylation is maintained in human cancer cells lacking DNMT1.

21 January 2018

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

21 January 2018

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DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).

21 January 2018

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The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

21 January 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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The establishment and maintenance of DNA methylation patterns in mouse somatic cells

21 January 2018

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Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.

21 January 2018

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Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

21 January 2018

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

21 January 2018

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Feedback regulation of DNA methyltransferase gene expression by methylation

21 January 2018

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Maintenance of genomic methylation requires a SWI2/SNF2-like protein.

21 January 2018

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Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis

21 January 2018

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Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1

21 January 2018

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Do intrinsic sex differences in lower alimentary tract physiology influence the sex-specific risks of bowel cancer and other biliary and intestinal diseases?

21 January 2018

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Incidence of colorectal adenocarcinoma by anatomic subsite. An epidemiologic study of time trends and racial differences in the Detroit, Michigan area.

21 January 2018

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Are dietary factors involved in DNA methylation associated with colon cancer?

21 January 2018

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Hypermethylation of tumor suppressor genes in cancer

21 January 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

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Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.

21 January 2018

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Mutations and altered expression of p16INK4 in human cancer.

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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A cell cycle regulator potentially involved in genesis of many tumor types

21 January 2018

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Role of the p16 tumor suppressor gene in cancer

21 January 2018

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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

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Abundance and state of phosphorylation of the retinoblastoma susceptibility gene product in human colon cancer

21 January 2018

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21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

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The cat and mouse games that genes, viruses, and cells play

21 January 2018

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DNA mismatch repair genes and colorectal cancer

21 January 2018

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Genetic instability in colorectal cancers

21 January 2018

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Genomic imprinting proposed as a surveillance mechanism for chromosome loss

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications

21 January 2018

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Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes

21 January 2018

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

21 January 2018

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Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer.

21 January 2018

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Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

21 January 2018

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Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers

21 January 2018

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The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers

21 January 2018

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Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers

21 January 2018

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Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

21 January 2018

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DNA repair: enzymatic mechanisms and relevance to drug response

21 January 2018

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Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

21 January 2018

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Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.

21 January 2018

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Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

21 January 2018

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Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 January 2018

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Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

21 January 2018

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

21 January 2018

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The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs)

21 January 2018

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Inhibition of cyclooxygenase-2 gene expression by p53.

21 January 2018

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Methylation and silencing of the Thrombospondin-1 promoter in human cancer.

21 January 2018

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 January 2018

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5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer

21 January 2018

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No SMAD4 hypermethylation in colorectal cancer

21 January 2018

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Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma

21 January 2018

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Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer

21 January 2018

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ABC of colorectal cancer: adjuvant therapy

21 January 2018

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Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation

21 January 2018

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Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

21 January 2018

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Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

21 January 2018

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Mismatch repair proficiency and in vitro response to 5-fluorouracil

21 January 2018

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

21 January 2018

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Overall deregulation in gene expression as a novel indicator of tumor aggressiveness in colorectal cancer.

21 January 2018

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

21 January 2018

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Epigenetics of inflammatory bowel disease

21 January 2018

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DNA hypomethylation in inflammatory arthritis: reversal with methotrexate

21 January 2018

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Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells

21 January 2018

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The effect of sodium butyrate on histone modification

21 January 2018

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Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region

21 January 2018

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Calcium - a life and death signal

21 January 2018

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Number of CpG islands and genes in human and mouse

21 January 2018

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MethDB--a public database for DNA methylation data

21 January 2018

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

21 January 2018

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A bird's eye view of global methylation

21 January 2018

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Hypermethylation of the p16 Gene in Sporadic T3N0M0 Stage Colorectal Cancers: Association with DNA Replication Error and Shorter Survival

21 January 2018

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Growing Y-junction carbon nanotubes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.923

1 reference

1 August 2017

1 reference

PubMed ID

11568897