(Q34379535)

1 August 2017

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. (English)

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1 August 2017

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7

Chen-Yang Shen

1 reference

1 August 2017

Jen-Hsuan Wei

1

1 reference

1 August 2017

Yi-Fan Chou

2

1 reference

1 August 2017

Yi-Hung Ou

3

1 reference

1 August 2017

Yen-Hsiu Yeh

4

1 reference

1 August 2017

Shiaw-Wei Tyan

5

1 reference

1 August 2017

Te-Ping Sun

6

1 reference

1 August 2017

Sheau-Yann Shieh

8

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1 August 2017

language of work or name

English

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publication date

23 December 2004

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Journal of Biological Chemistry

1 August 2017

10

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based on heuristic

inferred from page(s)

published in

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1 August 2017

280

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1 August 2017

7748-7757

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1 August 2017

9

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CHK2 kinase--a busy messenger.

1 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

A unified view of the DNA-damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

A kinase from fission yeast responsible for blocking mitosis in S phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The many substrates and functions of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Centrosomes and checkpoints: the MPS1 family of kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The mouse Mps1p-like kinase regulates centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

The spindle checkpoint, aneuploidy, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410152200

21 January 2018

Identifiers

DOI

10.1074/JBC.M410152200

1 reference

1 August 2017

1 reference