(Q34383525)

1 August 2017

title

Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance (English)

1 reference

1 August 2017

0 references

0 references

1 reference

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Yohei Shibuya

1

1 reference

1 August 2017

Catherine C Y Chang

2

1 reference

1 August 2017

Li-Hao Huang

3

1 reference

1 August 2017

Elena Y Bryleva

4

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1 August 2017

Ta-Yuan Chang

5

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1 August 2017

language of work or name

English

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publication date

1 October 2014

1 reference

1 August 2017

published in

Journal of Neuroscience

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1 August 2017

volume

34

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1 August 2017

issue

43

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1 August 2017

page(s)

14484-14501

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describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4205563/fullTextXML

inferred from PubMed Central ID database lookup

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TFEB links autophagy to lysosomal biogenesis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A gene network regulating lysosomal biogenesis and function

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

6 July 2018

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Acyl-coenzyme A:cholesterol acyltransferases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

6 July 2018

1 reference

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

6 July 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

6 July 2018

1 reference

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ApoE promotes the proteolytic degradation of Abeta

6 July 2018

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Active and passive immunotherapy for neurodegenerative disorders

6 July 2018

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Autophagy fights disease through cellular self-digestion

6 July 2018

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Autophagy: process and function

6 July 2018

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Alzheimer's disease: the lipid connection

6 July 2018

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Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation

6 July 2018

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6 July 2018

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6 July 2018

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Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs

6 July 2018

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Cholesterol depletion induces autophagy

6 July 2018

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Autophagy is activated for cell survival after endoplasmic reticulum stress

6 July 2018

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6 July 2018

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ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis

6 July 2018

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6 July 2018

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Liver X receptors as integrators of metabolic and inflammatory signaling

6 July 2018

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Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts

6 July 2018

1 reference

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Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein

6 July 2018

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

6 July 2018

1 reference

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

6 July 2018

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6 July 2018

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

6 July 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

6 July 2018

1 reference

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

6 July 2018

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Acyl-coenzyme A:cholesterol acyltransferase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

6 July 2018

1 reference

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Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 2. Effect of sterol endogenously synthesized

6 July 2018

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Regulation of the mevalonate pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

The picomole determination of free and total cholesterol in cells in culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

The pharmacology of mTOR inhibition

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

High-yield isolation of murine microglia by mild trypsinization.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4205563

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

27 October 2018

1 reference

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Isolation and culture of adult rat hippocampal neurons

27 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25339759

12 December 2020

inferred from PubMed ID database lookup

Use of cyclodextrins for manipulating cellular cholesterol content

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25339759

12 December 2020

inferred from PubMed ID database lookup

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25339759

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.2567-14.2014

1 reference

1 August 2017

1 reference

1 August 2017

1 reference