(Q34052428)

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The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.

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7 February 2020

The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice (English)

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7 February 2020

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Henri J. Huttunen

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7 February 2020

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Matthew P Frosch

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7 February 2020

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Daniel Havas

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7 February 2020

Camilla Peach

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7 February 2020

Cory Barren

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7 February 2020

Stephan Duller

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7 February 2020

Weiming Xia

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7 February 2020

Birgit Hutter-Paier

8

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7 February 2020

Manfred Windisch

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7 February 2020

Dora M Kovacs

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7 February 2020

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1 August 2010

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7 February 2020

Journal of Neuropathology & Experimental Neurology

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7 February 2020

69

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7 February 2020

8

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7 February 2020

777-788

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7 February 2020

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

1 reference

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5 July 2018

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

1 reference

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5 July 2018

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Statins--a cure-all for the brain?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Acyl coenzyme A:cholesterol acyltransferase inhibitors as hypolipidemic and antiatherosclerotic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Deciphering the molecular basis of memory failure in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Pathways towards and away from Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Inflammation occurs early during the Abeta deposition process in TgCRND8 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

A method of direct measurement for the enzymatic determination of cholesteryl esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Alzheimer's disease: the cholesterol connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Pharmacology of the ACAT inhibitor avasimibe (CI-1011).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Down syndrome and Alzheimer's disease: a link between development and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Microglia-specific localisation of a novel calcium binding protein, Iba1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

5 July 2018

Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Characterization of the Drosophila melanogaster genome at the nuclear lamina.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

1 reference

https://api.crossref.org/works/10.1097%2FNEN.0B013E3181E77ED9

21 January 2018

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

28 October 2018

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918281

28 October 2018

Patterns of gliosis in Alzheimer's disease and aging cerebrum

1 reference

https://pubmed.ncbi.nlm.nih.gov/20613640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20613640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins as a newly recognized type of immunomodulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/20613640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20613640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/NEN.0B013E3181E77ED9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20613640%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20613640%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20613640%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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